C3 (komplement)

C3 (komplement)
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4ONT, 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB, 2XWJ, 3D5R, 3D5S, 3G6J, 3L3O, 3L5N, 3NMS, 3OED, 3OHX, 3OXU, 3RJ3, 3T4A, 4HW5, 4HWJ, 4I6O, 4M76, 4ZH1, 5FOB, 5FO9, 5FO7, 5FO8, 5FOA
Identifikatori
Aliasi	C3
Vanjski ID-jevi	OMIM: 120700 MGI: 88227 HomoloGene: 68031 GeneCards: C3
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19p13.3 Početak 6,677,704 bp[1] Kraj 6,730,562 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 D|17 29.72 cM Početak 57,510,970 bp[2] Kraj 57,535,136 bp[2]
Ontologija gena Molekularna funkcija • C5L2 anaphylatoxin chemotactic receptor binding • GO:0001948, GO:0016582 vezivanje za proteine • endopeptidase inhibitor activity • signaling receptor binding • serine-type endopeptidase activity Ćelijska komponenta • blood microparticle • ćelijska membrana • Vanćelijska tečnost • extracellular region • Egzosom Biološki proces • G protein-coupled receptor signaling pathway • positive regulation of phagocytosis • positive regulation of protein phosphorylation • complement activation, alternative pathway • lipid metabolism • immune system process • complement activation • positive regulation of lipid storage • positive regulation of type IIa hypersensitivity • fatty acid metabolic process • positive regulation of angiogenesis • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of apoptotic cell clearance • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • complement activation, classical pathway • regulation of immune response • positive regulation of activation of membrane attack complex • positive regulation of vascular endothelial growth factor production • inflammatory response • positive regulation of glucose transmembrane transport • regulation of complement activation • GO:0072468 Transdukcija signala • negative regulation of endopeptidase activity • regulation of triglyceride biosynthetic process • Proteoliza • Urođeni imunski sistem Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	718	12266
Ensembl	ENSG00000125730	ENSMUSG00000024164
UniProt	P01024	P01027
RefSeq (mRNK)	NM_000064	NM_009778
RefSeq (bjelančevina)	NP_000055	NP_033908
Lokacija (UCSC)	Chr 19: 6.68 – 6.73 Mb	Chr 17: 57.51 – 57.54 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Komplementna komponenta 3, znana i kao C3, jest protein imunskog sistema koji je kod ljudi kodiran genom C3 sa hromosoma 19. Ima centralnu ulogu u komplementnom sistemu i doprinosi urođenoj imunosti.^[5][6]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000125730 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000024164 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ de Bruijn MH, Fey GH (Feb 1985). "Human complement component C3: cDNA coding sequence and derived primary structure". Proceedings of the National Academy of Sciences of the United States of America. 82 (3): 708–12. Bibcode:1985PNAS...82..708D. doi:10.1073/pnas.82.3.708. PMC 397115. PMID 2579379.
6. ^ "Entrez Gene: C3 complement component 3".