CCL21

CCL21
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2L4N
Identifikatori
Aliasi	CCL21
Vanjski ID-jevi	OMIM: 602737 MGI: 1349183 HomoloGene: 2247 GeneCards: CCL21
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek)[1] Bend 9p13.3 Početak 34,709,005 bp[1] Kraj 34,710,136 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 A5|4 22.81 cM Početak 42,772,860 bp[2] Kraj 42,773,993 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • cytokine activity • chemokine receptor binding • CCR7 chemokine receptor binding • chemokine activity • CCR chemokine receptor binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of leukocyte tethering or rolling • release of sequestered calcium ion into cytosol • positive regulation of receptor-mediated endocytosis • positive regulation of protein kinase B signaling • positive regulation of cell motility • positive regulation of actin filament polymerization • monocyte chemotaxis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • ruffle organization • positive regulation of cell-matrix adhesion • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • T cell costimulation • cell maturation • positive regulation of JNK cascade • dendritic cell chemotaxis • negative regulation of dendritic cell dendrite assembly • positive regulation of phosphatidylinositol 3-kinase activity • Hemotaksija • response to prostaglandin E • positive regulation of dendritic cell antigen processing and presentation • dendritic cell dendrite assembly • positive regulation of pseudopodium assembly • mesangial cell-matrix adhesion • positive regulation of chemotaxis • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • establishment of T cell polarity • positive regulation of ERK1 and ERK2 cascade • positive regulation of glycoprotein biosynthetic process • cellular response to interferon-gamma • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell chemotaxis • lymphocyte chemotaxis • positive regulation of neutrophil chemotaxis • positive regulation of cell adhesion mediated by integrin • immunological synapse formation • positive regulation of filopodium assembly • positive regulation of T cell migration • positive regulation of myeloid dendritic cell chemotaxis • positive regulation of protein kinase activity • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • negative regulation of dendritic cell apoptotic process • positive regulation of T cell chemotaxis • neutrophil chemotaxis • chemokine (C-C motif) ligand 21 signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to chemokine Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6366	18829
Ensembl	ENSG00000137077	ENSMUSG00000094686
UniProt	O00585	P84444
RefSeq (mRNK)	NM_002989	NM_011124
RefSeq (bjelančevina)	NP_002980	NP_035254
Lokacija (UCSC)	Chr 9: 34.71 – 34.71 Mb	Chr 4: 42.77 – 42.77 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 21 (CCL21) jest mali citokin hemokinske porodice CC. Ovaj hemokin je poznat i kao 6Ckin (jer ima šest konzerviranih cisteinskih ostataka umjesto četiri cisteina tipska za hemokine), egzodus-2 i sekundarni limfoidni tkivni hemokin (SLC).^[5][6][7]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137077 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000094686 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hedrick JA, Zlotnik A (august 1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". Journal of Immunology. 159 (4): 1589–93. PMID 9257816.
6. ^ Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (septembar 1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". Journal of Immunology. 159 (6): 2554–8. PMID 9300671.
7. ^ Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (august 1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". The Journal of Biological Chemistry. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.