Faktor XI

F11
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1XX9, 1XXD, 1XXF, 1ZHM, 1ZHP, 1ZHR, 1ZJD, 1ZLR, 1ZMJ, 1ZML, 1ZMN, 1ZOM, 1ZPB, 1ZPC, 1ZPZ, 1ZRK, 1ZSJ, 1ZSK, 1ZSL, 1ZTJ, 1ZTK, 1ZTL, 2F83, 2FDA, 2J8J, 2J8L, 3BG8, 3SOR, 3SOS, 4CR5, 4CR9, 4CRA, 4CRB, 4CRC, 4CRD, 4CRE, 4CRF, 4CRG, 4NA7, 4NA8, 4TY6, 4TY7, 4WXI, 4X6M, 4X6N, 4X6O, 4X6P, 4Y8X, 4Y8Y, 4Y8Z, 4D7F, 5E2O, 5E2P, 4D76, 4D7G, 5EXL, 5I25, 5EXM, 5EOD, 5EXN, 5EOK
Identifikatori
Aliasi	F11
Vanjski ID-jevi	OMIM: 264900 MGI: 99481 HomoloGene: 86654 GeneCards: F11
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q35.2 Početak 186,266,189 bp[1] Kraj 186,289,681 bp[1]
Lokacija gena (miš) Hrom. Hromosom 8 (miš)[2] Bend 8 B1.1|8 25.14 cM Početak 45,694,211 bp[2] Kraj 45,715,068 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • serine-type aminopeptidase activity • GO:0070122 peptidase activity • heparin binding • serine-type endopeptidase activity • serine-type peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • vezivanje identičnih proteina Ćelijska komponenta • extracellular region • ćelijska membrana • Egzosom • membrana • Vanćelijsko Biološki proces • Hemostaza • blood coagulation, intrinsic pathway • plasminogen activation • regulation of blood coagulation • Proteoliza • positive regulation of fibrinolysis • Koagulacija (krv) Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2160	109821
Ensembl	ENSG00000088926	ENSMUSG00000031645
UniProt	P03951	Q91Y47
RefSeq (mRNK)	NM_000128 NM_019559 NM_001354804	NM_028066
RefSeq (bjelančevina)	NP_000119 NP_001341733	NP_082342
Lokacija (UCSC)	Chr 4: 186.27 – 186.29 Mb	Chr 8: 45.69 – 45.72 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Faktor XI ili plazmatski tromboplastinski prethodnik jest protein koji je kod ljudi kodiran genom F11 sa hromosoma 4. To je zimogeni oblik faktora XIa, jedan od enzima u koagulacijskoj kaskadi. Kao i mnogi drugi faktori koagulacije, to je serin-proteaza.^[5][6][7][8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000088926 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000031645 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Šablon:EVC.PNGcite journal
6. ^ Asakai R, Davie EW, Chung DW (Nov 1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221–8. doi:10.1021/bi00397a004. PMID 2827746.
7. ^ Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenetics and Cell Genetics. 52 (1–2): 77–8. doi:10.1159/000132844. PMID 2612218.
8. ^ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ (maj 1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". American Journal of Human Genetics. 48 (5): 911–25. PMC 1683054. PMID 1673289.