Faktor nervnog rasta

NGF
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identifikatori
Aliasi	NGF
Vanjski ID-jevi	OMIM: 162030 MGI: 97321 HomoloGene: 1876 GeneCards: NGF
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p13.2 Početak 115,285,904 bp[1] Kraj 115,338,770 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 F2.2|3 45.25 cM Početak 102,377,235 bp[2] Kraj 102,428,329 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • peptidase inhibitor activity • GO:0048551 enzyme inhibitor activity • GO:0001948, GO:0016582 vezivanje za proteine • metalloendopeptidase inhibitor activity • nerve growth factor receptor binding • growth factor activity • signaling receptor binding Ćelijska komponenta • endozom • Golgi lumen • extracellular region • GO:0016023 citoplazmatska vezikula • Vanćelijsko • citosol • Sinapsna vezikula • Akson • dendrit Biološki proces • GO:1904089 negative regulation of neuron apoptotic process • regulation of neuron differentiation • neuron projection morphogenesis • negative regulation of peptidase activity • neurotrophin TRK receptor signaling pathway • cell-cell signaling • negative regulation of apoptotic process • regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of axonogenesis • GO:1901313 positive regulation of gene expression • positive regulation of apoptotic process • nerve growth factor processing • extrinsic apoptotic signaling pathway via death domain receptors • phosphatidylinositol-mediated signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • microtubule-based movement • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of Ras protein signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • peripheral nervous system development • Memorija • negative regulation of cell population proliferation • regulation of signaling receptor activity • nerve development • nerve growth factor signaling pathway • positive regulation of DNA binding • positive regulation of neuron differentiation • positive regulation of collateral sprouting • modulation of chemical synaptic transmission Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4803	18049
Ensembl	ENSG00000134259	ENSMUSG00000027859
UniProt	P01138	P01139
RefSeq (mRNK)	NM_002506	NM_001112698 NM_013609
RefSeq (bjelančevina)	NP_002497	NP_001106168 NP_038637
Lokacija (UCSC)	Chr 1: 115.29 – 115.34 Mb	Chr 3: 102.38 – 102.43 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Faktor nervnog rasta (NGF) je neurotrofni faktor i neuropeptid koji je prvenstveno uključen u regulaciju rfasta. održavanje, proliferaciju i preživljavanje određenih ciljnih neurono. To jest protein koji je kod ljudi kodiran genom NFG sa hromosoma 1. To je možda prototip faktora rasta, po tome što je bio jedan od prvih koji je opisan. Otkako su ga prvi put izolovali nobelovci Rita Levi-Montalcini i Stanley Cohen 1956. godine, identificirani su brojni biološki procesi koji uključuju NGF, a dva od njih su opstanak beta ćelija gušterače i regulacija imunskog sistema.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000134259 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000027859 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.