GFAP

GFAP
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 6A9P
Identifikatori
Aliasi	GFAP
Vanjski ID-jevi	OMIM: 137780 MGI: 95697 HomoloGene: 1554 GeneCards: GFAP
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q21.31 Početak 44,903,159 bp[1] Kraj 44,916,937 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 E1|11 66.48 cM Početak 102,778,162 bp[2] Kraj 102,791,738 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • structural molecule activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • integrin binding • structural constituent of cytoskeleton • kinase binding Ćelijska komponenta • citoplazma • citosol • Lizozom • Intermedijarni filament • intracellular anatomical structure • membrana • projekcija ćelije • myelin sheath • cell body • glial cell projection • astrocyte projection • astrocyte end-foot • cytoplasmic side of lysosomal membrane • citoskelet Biološki proces • GO:0106159 regulation of protein-containing complex assembly • response to wounding • positive regulation of Schwann cell proliferation • negative regulation of neuron projection development • astrocyte development • extracellular matrix organization • neuron projection regeneration • intermediate filament-based process • regulation of neurotransmitter uptake • Bergmann glial cell differentiation • positive regulation of glial cell proliferation • long-term potentiation • regulation of chaperone-mediated autophagy • intermediate filament organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2670	14580
Ensembl	ENSG00000131095	ENSMUSG00000020932
UniProt	P14136	P03995
RefSeq (mRNK)	NM_002055 NM_001131019 NM_001242376 NM_001363846	NM_001131020 NM_010277
RefSeq (bjelančevina)	NP_001124491 NP_001229305 NP_002046 NP_001350775	NP_001124492 NP_034407
Lokacija (UCSC)	Chr 17: 44.9 – 44.92 Mb	Chr 11: 102.78 – 102.79 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Glijski vlaknasti kiseli protein (GFAP) je protein koji je kod ljudi kodiran genom GFAP.^[5] To je protein intermedijarnog filamenta tipa III (IF) koji se eksprimira brojnim tipovima ćelija centralnog nervnog sistema (CNS), uključujući astrocite ^[6] i ependimne ćelije tokom razvoja .^[7] Također je utvrđeno da se GFAP eksprimira u glomerulima i peritubulskim fibroblastima iz bubrega pacova,^[8] Leydigove ćelije testisa i kod hrčka^[9] i ljudi,^[10] ljudskih keratinocita,^[11]osteocita i hondrocita^[12] i zvjezdanih ćelija pankreasa i jetre kod pacova.^[13]

GFAP je usko povezan sa ostala tri člana porodice koji nisu epitelni tip IF, vimentin, dezmin i periferin, koji su svi uključeni u strukturu i funkciju ćelijskog citoskeleta. Smatra se da GFAP pomaže u održavanju mehaničke čvrstoće astrocita ^[14] kao i oblik ćelija, ali njegova tačna funkcija ostaje slabo razumljiva, uprkos brojnim studijama koje ga koriste kao ćelijski marker. Protein je imenovao i prvi izolirao i okarakterizirao Lawrence F. Eng, 1969.^[15] U ljudi, nalazi se na dugom (q) kraku hromosoma 17.^[16]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000131095 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000020932 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Isaacs A, Baker M, Wavrant-De Vrièze F, Hutton M (juli 1998). "Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17". Genomics. 51 (1): 152–4. doi:10.1006/geno.1998.5360. PMID 9693047.
6. ^ Jacque CM, Vinner C, Kujas M, Raoul M, Racadot J, Baumann NA (januar 1978). "Determination of glial fibrillary acidic protein (GFAP) in human brain tumors". Journal of the Neurological Sciences. 35 (1): 147–55. doi:10.1016/0022-510x(78)90107-7. PMID 624958. S2CID 10224197.
7. ^ Roessmann U, Velasco ME, Sindely SD, Gambetti P (oktobar 1980). "Glial fibrillary acidic protein (GFAP) in ependymal cells during development. An immunocytochemical study". Brain Research. 200 (1): 13–21. doi:10.1016/0006-8993(80)91090-2. PMID 6998542. S2CID 38131934.
8. ^ Buniatian G, Traub P, Albinus M, Beckers G, Buchmann A, Gebhardt R, Osswald H (januar 1998). "The immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture". Biology of the Cell. 90 (1): 53–61. doi:10.1016/s0248-4900(98)80232-3. PMID 9691426. S2CID 31851422.
9. ^ Maunoury R, Portier MM, Léonard N, McCormick D (decembar 1991). "Glial fibrillary acidic protein immunoreactivity in adrenocortical and Leydig cells of the Syrian golden hamster (Mesocricetus auratus)". Journal of Neuroimmunology. 35 (1–3): 119–29. doi:10.1016/0165-5728(91)90167-6. PMID 1720132. S2CID 3766335.
10. ^ Davidoff MS, Middendorff R, Köfüncü E, Müller D, Jezek D, Holstein AF (2002). "Leydig cells of the human testis possess astrocyte and oligodendrocyte marker molecules". Acta Histochemica. 104 (1): 39–49. doi:10.1078/0065-1281-00630. PMID 11993850.
11. ^ von Koskull H (1984). "Rapid identification of glial cells in human amniotic fluid with indirect immunofluorescence". Acta Cytologica. 28 (4): 393–400. PMID 6205529.
12. ^ Kasantikul V, Shuangshoti S (maj 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". Journal of Surgical Oncology. 41 (1): 22–6. doi:10.1002/jso.2930410109. PMID 2654484. S2CID 34069861.
13. ^ Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, et al. (juli 1998). "Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture". Gut. 43 (1): 128–33. doi:10.1136/gut.43.1.128. PMC 1727174. PMID 9771417.
14. ^ Cullen DK, Simon CM, LaPlaca MC (juli 2007). "Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures". Brain Research. 1158: 103–15. doi:10.1016/j.brainres.2007.04.070. PMC 3179863. PMID 17555726.
15. ^ Eng LF, Ghirnikar RS, Lee YL (oktobar 2000). "Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)". Neurochemical Research. 25 (9–10): 1439–51. doi:10.1023/A:1007677003387. PMID 11059815. S2CID 9221868.
16. ^ Bongcam-Rudloff E, Nistér M, Betsholtz C, Wang JL, Stenman G, Huebner K, et al. (mart 1991). "Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes". Cancer Research. 51 (5): 1553–60. PMID 1847665.