IGF2R

IGF2R
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2V5N, 2V5O, 2V5P, 2L29, 2L2A, 2M68, 5IEI, 2M6T
Identifikatori
Aliasi	IGF2R
Vanjski ID-jevi	OMIM: 147280 MGI: 96435 HomoloGene: 676 GeneCards: IGF2R
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6q25.3 Početak 159,969,082 bp[1] Kraj 160,113,507 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 A1|17 8.64 cM Početak 12,901,293 bp[2] Kraj 12,988,551 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • retinoic acid binding • insulin-like growth factor binding • G protein-coupled receptor activity • transporter activity • phosphoprotein binding • insulin-like growth factor-activated receptor activity • insulin-like growth factor II binding • mannose binding • vezivanje identičnih proteina • vezivanje enzima • G-protein alpha-subunit binding • GO:0001948, GO:0016582 vezivanje za proteine • kringle domain binding • signaling receptor activity Ćelijska komponenta • citoplazma • integral component of membrane • endozom • late endosome • membrana • focal adhesion • clathrin coat • endocytic vesicle • integral component of plasma membrane • cell surface • lysosomal membrane • trans-Golđijeva mreža • early endosome • nuclear envelope lumen • perinuklearno područje citoplazme • trans-Golgi network transport vesicle • Lizozom • Egzosom • jedro • trans-Golgi network membrane • transport vesicle • Vanćelijsko • Golđijev aparat • ćelijska membrana • clathrin-coated vesicle membrane • secretory granule membrane • clathrin-coated vesicle Biološki proces • regulation of apoptotic process • G protein-coupled receptor signaling pathway • response to retinoic acid • post-embryonic development • receptor-mediated endocytosis • animal organ regeneration • Spermatogeneza • positive regulation of apoptotic process • liver development • GO:0072468 Transdukcija signala • insulin-like growth factor receptor signaling pathway • neutrophil degranulation • membrane organization • GO:0015915 transport • post-Golgi vesicle-mediated transport • lysosomal transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3482	16004
Ensembl	ENSG00000197081	ENSMUSG00000023830
UniProt	P11717	Q07113
RefSeq (mRNK)	NM_000876	NM_010515
RefSeq (bjelančevina)	NP_000867	NP_034645
Lokacija (UCSC)	Chr 6: 159.97 – 160.11 Mb	Chr 17: 12.9 – 12.99 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor insulinolikog faktora rasta 2 (IGF2R), znan i kao kation-neovisni receptor manoza-6-fosfata (CI-MPR) jest protein koji je kod ljudi kodiran genom IGF2R.^[5][6] IGF2R je multifunkcionalni proteinski receptor koji se veže insulinski faktor rasta 2 (IGF2) na ćelijskoj površini i manoza-6-fosfat (M6P) označeni protein u trans-Golgijevoj mreži.^[6]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000197081 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000023830 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (februar 1988). "The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553–62. doi:10.1016/S0021-9258(18)69243-9. PMID 2963003.
6. ^ ^{a b} Laureys G, Barton DE, Ullrich A, Francke U (oktobar 1988). "Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse". Genomics. 3 (3): 224–9. doi:10.1016/0888-7543(88)90083-3. PMID 2852162.