IGJ

IGJ
Identifikatori
Aliasi	JCHAIN
Vanjski ID-jevi	OMIM: 147790 MGI: 96493 HomoloGene: 16958 GeneCards: JCHAIN
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q13.3 Početak 70,655,541 bp[1] Kraj 70,681,817 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 E1 Početak 88,667,668 bp[2] Kraj 88,675,750 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0003823, GO:0051635 antigen binding • protein homodimerization activity • phosphatidylcholine binding • immunoglobulin receptor binding • single-stranded DNA binding • peptidoglycan binding • IgA binding • protein-macromolecule adaptor activity Ćelijska komponenta • secretory IgA immunoglobulin complex • blood microparticle • hexameric IgM immunoglobulin complex • monomeric IgA immunoglobulin complex • dimeric IgA immunoglobulin complex • pentameric IgM immunoglobulin complex • secretory dimeric IgA immunoglobulin complex • Egzosom • extracellular region • Vanćelijsko Biološki proces • adaptive immune response • retina homeostasis • glomerular filtration • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • Urođeni imunski sistem • positive regulation of respiratory burst • receptor-mediated endocytosis • positive regulation of protein oligomerization • leukocyte migration Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3512	16069
Ensembl	ENSG00000132465	ENSMUSG00000067149
UniProt	P01591	P01592
RefSeq (mRNK)	NM_144646	NM_152839
RefSeq (bjelančevina)	NP_653247	NP_690052
Lokacija (UCSC)	Chr 4: 70.66 – 70.68 Mb	Chr 5: 88.67 – 88.68 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

J lanac imunoglobulina jest proteinska komponenta antitijela IgM i IgA, koji je kod ljudi kodiran genom IGJ sa hromosoma 4.^[5] Ima 137 polipeptidnih ostataka.^[6][7][8][9]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000132465 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000067149 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Levinson (2014). Medical Microbiology and Immunology (11 izd.). McGrawHill. str. 405–6.
6. ^ Greška kod citiranja: Nevaljana oznaka <ref>; nije naveden tekst za reference s imenom Paul0804
7. ^ Max EE, McBride OW, Morton CC, Robinson MA (Sep 1986). "Human J chain gene: chromosomal localization and associated restriction fragment length polymorphisms". Proc Natl Acad Sci U S A. 83 (15): 5592–6. Bibcode:1986PNAS...83.5592M. doi:10.1073/pnas.83.15.5592. PMC 386334. PMID 3016707.
8. ^ Max EE, Korsmeyer SJ (maj 1985). "Human J chain gene. Structure and expression in B lymphoid cells". J Exp Med. 161 (4): 832–49. doi:10.1084/jem.161.4.832. PMC 2189063. PMID 2984306.
9. ^ "Entrez Gene: IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides".