Insulinoliki faktor rasta 1

Insulinoliki faktor rasta 1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS

Identifikatori
AliasiIGF1
Vanjski ID-jeviOMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za Insulinoliki faktor rasta 1
Genomska lokacija za Insulinoliki faktor rasta 1
Bend12q23.2Početak102,395,874 bp[1]
Kraj102,481,744 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za Insulinoliki faktor rasta 1
Genomska lokacija za Insulinoliki faktor rasta 1
Bend10 C1|10 43.7 cMPočetak87,694,127 bp[2]
Kraj87,772,904 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija hormone activity
insulin receptor binding
growth factor activity
integrin binding
GO:0001948, GO:0016582 vezivanje za proteine
insulin-like growth factor receptor binding
Ćelijska komponenta extracellular region
exocytic vesicle
insulin-like growth factor binding protein complex
platelet alpha granule lumen
insulin-like growth factor ternary complex
alphav-beta3 integrin-IGF-1-IGF1R complex
ćelijska membrana
Vanćelijsko
Biološki proces positive regulation of transcription regulatory region DNA binding
skeletal system development
positive regulation of glucose import
muscle organ development
positive regulation of Ras protein signal transduction
response to heat
positive regulation of cardiac muscle hypertrophy
positive regulation of smooth muscle cell migration
Replikacija DNK
positive regulation of insulin-like growth factor receptor signaling pathway
phosphatidylinositol 3-kinase signaling
positive regulation of DNA binding
Ras protein signal transduction
Ćelijska proliferacija
positive regulation of mitotic nuclear division
positive regulation of trophectodermal cell proliferation
positive regulation of glycogen biosynthetic process
positive regulation of fibroblast proliferation
ERK1 and ERK2 cascade
negative regulation of extrinsic apoptotic signaling pathway
cell activation
negative regulation of oocyte development
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
bone mineralization involved in bone maturation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of MAPK cascade
proteoglycan biosynthetic process
positive regulation of activated T cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of release of cytochrome c from mitochondria
protein stabilization
myotube cell development
positive regulation of DNA replication
myoblast proliferation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
positive regulation of protein secretion
positive regulation of glycoprotein biosynthetic process
Regulacija ekspresije gena
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
muscle hypertrophy
protein kinase B signaling
regulation of multicellular organism growth
positive regulation of cell migration
platelet degranulation
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of phosphatidylinositol 3-kinase signaling
myoblast differentiation
glycolate metabolic process
positive regulation of glycolytic process
negative regulation of smooth muscle cell apoptotic process
GO:0072468 Transdukcija signala
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of cell population proliferation
positive regulation of osteoblast differentiation
activation of protein kinase B activity
insulin-like growth factor receptor signaling pathway
negative regulation of apoptotic process
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
GO:1901313 positive regulation of gene expression
negative regulation of gene expression
cellular response to amyloid-beta
positive regulation of vascular associated smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell apoptotic process
negative regulation of interleukin-1 beta production
negative regulation of tumor necrosis factor production
negative regulation of neuroinflammatory response
negative regulation of amyloid-beta formation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_000618
NM_001111283
NM_001111284
NM_001111285

NM_001111274
NM_001111275
NM_001111276
NM_010512
NM_184052

NM_001314010

RefSeq (bjelančevina)

NP_000609
NP_001104753
NP_001104754
NP_001104755

NP_001104744
NP_001104745
NP_001104746
NP_001300939
NP_034642

Lokacija (UCSC)Chr 12: 102.4 – 102.48 MbChr 10: 87.69 – 87.77 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Insulinoliki faktor rasta 1 (IGF-1) – poznat i kao somatomedin C – je a hormon koji je sličan molekulskoj strukturi insulina. Ima značajnu ulogu u rastu tokom djetinjstva, a kod odraslih ima anaboličke efekte.

IGF-1 je protein kojeg kod čovjeka kodira gen IGF1.[5][6] IGF-1 sadrži 70 aminokiselina, u jednostrukom lancu sa tri unutarmolekulska disulfidna mosta. Molekulska težina mu je 7.649 daltona.[7]

IGF-1 se prvenstveno proizvodi u jetri. Proizvodnju stimulira hormon rasta (GH). Većina IGF-1 vezana je za jedan od 6 vežućih proteina (IGF-BP). IGFBP-1 regulira insulin. IGF-1 se proizvodi tokom čitavog života; najveće stope proizvodnje IGF-1 javljaju se tokom mladalačkog rasta. Najniži nivo se javlja kod novorođenčadi i u starosti.

Sintetski analog IGF-1, mekasermin, koristi se u djece za liječenje zatajenja rasta.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985). "The human gene encoding insulin-like growth factor I is located on chromosome 12". Hum. Genet. 69 (2): 157–60. doi:10.1007/BF00293288. PMID 2982726.
  6. ^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983). "Sequence of cDNA encoding human insulin-like growth factor I precursor". Nature. 306 (5943): 609–11. doi:10.1038/306609a0. PMID 6358902.
  7. ^ Rinderknecht E, Humbel RE (1978). "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin". J Biol Chem. 253 (8): 2769–2776. PMID 632300.
  8. ^ Keating GM (2008). "Mecasermin". BioDrugs. 22 (3): 177–88. doi:10.2165/00063030-200822030-00004. PMID 18481900.

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