Insulinoliki faktor rasta 2

Insulinoliki faktor rasta 2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3KR3, 1IGL, 2L29, 2V5P, 3E4Z
Identifikatori
Aliasi	IGF2
Vanjski ID-jevi	OMIM: 147470 MGI: 96434 HomoloGene: 510 GeneCards: IGF2
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.5 Početak 2,129,112 bp[1] Kraj 2,158,391 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 F5|7 87.99 cM Početak 142,204,503 bp[2] Kraj 142,220,553 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • insulin receptor binding • hormone activity • GO:0001948, GO:0016582 vezivanje za proteine • growth factor activity • insulin-like growth factor receptor binding • integrin binding • protein serine/threonine kinase activator activity • receptor ligand activity Ćelijska komponenta • extracellular region • platelet alpha granule lumen • Vanćelijsko Biološki proces • regulation of gene expression by genetic imprinting • skeletal system development • GO:1901047 insulin receptor signaling pathway • positive regulation of protein kinase B signaling • GO:0009373 regulation of transcription, DNA-templated • ossification • platelet degranulation • multicellular organism development • glucose metabolic process • positive regulation of mitotic nuclear division • positive regulation of cell division • positive regulation of MAPK cascade • positive regulation of activated T cell proliferation • positive regulation of protein serine/threonine kinase activity • carbohydrate metabolic process • regulation of signaling receptor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • osteoblast differentiation • in utero embryonic development • embryonic placenta development • positive regulation of protein phosphorylation • positive regulation of cell population proliferation • animal organ morphogenesis • exocrine pancreas development • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification • insulin receptor signaling pathway via phosphatidylinositol 3-kinase • positive regulation of multicellular organism growth • GO:0048554 positive regulation of catalytic activity • positive regulation of glycogen biosynthetic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:1903106 positive regulation of insulin receptor signaling pathway • positive regulation of peptidyl-tyrosine phosphorylation • striated muscle cell differentiation • regulation of muscle cell differentiation • embryonic placenta morphogenesis • positive regulation of glycogen (starch) synthase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3481	16002
Ensembl	ENSG00000167244	ENSMUSG00000048583
UniProt	P01344	P09535
RefSeq (mRNK)	NM_001291862 NM_000612 NM_001007139 NM_001127598 NM_001291861	NM_001122736 NM_001122737 NM_010514 NM_001315488 NM_001315489
RefSeq (bjelančevina)	NP_000603 NP_001007140 NP_001121070 NP_001278790 NP_001278791	NP_001116208 NP_001116209 NP_001302417 NP_001302418 NP_034644
Lokacija (UCSC)	Chr 11: 2.13 – 2.16 Mb	Chr 7: 142.2 – 142.22 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Insulinoliki faktor rasta 2 (IGF-2), jedan je od tri proteinska hormon koji imaju strukturnu sličnost sa insulinom. Definicija MeSH glasi: "Dobro karakterizirani neutralni peptid za koji se vjeruje da ga jetra luči i da cirkulira u krvi. Ima aktivnosti regulacije rasta, slične insulinu i mitogenima. Faktor rasta ima glavnu ulogu, ali ne i apsolutnu, ovisno o somatotropinu. Vjeruje se da je glavni faktor rasta i fetusa, za razliku od insulinolikog faktor rasta 1, koji je glavni faktor rasta kod odraslih"^[5]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000167244 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000048583 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Insulin-Like Growth Factor II". MeSH. NCBI.