Leptin

Leptin
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1AX8
Identifikatori
Aliasi	LEP
Vanjski ID-jevi	OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7q32.1 Početak 128,241,278 bp[1] Kraj 128,257,629 bp[1]
Lokacija gena (miš) Hrom. Hromosom 6 (miš)[2] Bend 6 A3.3|6 12.3 cM Početak 29,060,219 bp[2] Kraj 29,073,876 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hormone activity • peptide hormone receptor binding • signaling receptor binding Ćelijska komponenta • citoplazma • extracellular region • Vanćelijsko Biološki proces • regulation of protein phosphorylation • response to dietary excess • cellular response to retinoic acid • positive regulation of developmental growth • negative regulation of glucagon secretion • Placentacija • cardiac muscle hypertrophy • regulation of angiogenesis • prostaglandin secretion • regulation of intestinal cholesterol absorption • T cell differentiation • positive regulation of reactive oxygen species metabolic process • central nervous system neuron development • Jednodnevni biološki ritam • positive regulation of ion transport • Angiogeneza • glucose metabolic process • positive regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of hepatic stellate cell activation • regulation of endothelial cell proliferation • intestinal absorption • response to ethanol • negative regulation of autophagy • positive regulation of p38MAPK cascade • positive regulation of protein kinase B signaling • negative regulation of metabolic process • negative regulation of vasoconstriction • glucose homeostasis • regulation of insulin secretion • regulation of steroid biosynthetic process • insulin secretion • regulation of natural killer cell activation • regulation of fat cell differentiation • response to vitamin E • response to nutrient levels • bone mineralization involved in bone maturation • positive regulation of T cell proliferation • positive regulation of protein import into nucleus • regulation of brown fat cell differentiation • fatty acid beta-oxidation • regulation of metabolic process • hormone metabolic process • positive regulation of MAPK cascade • positive regulation of TOR signaling • cellular response to L-ascorbic acid • ovulation from ovarian follicle • activation of protein kinase C activity • spolno razmnožavanje • negative regulation of cartilage development • response to nutrient • negative regulation of glutamine transport • leptin-mediated signaling pathway • bile acid metabolic process • female pregnancy • negative regulation of apoptotic process • cholesterol metabolic process • positive regulation of follicle-stimulating hormone secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of appetite • regulation of protein localization to nucleus • regulation of blood pressure • negative regulation of glucose import • leukocyte tethering or rolling • negative regulation of lipid storage • adipose tissue development • GO:1903106 positive regulation of insulin receptor signaling pathway • bone growth • positive regulation of receptor signaling pathway via JAK-STAT • glycerol biosynthetic process • positive regulation of luteinizing hormone secretion • fatty acid catabolic process • regulation of gluconeogenesis • response to estradiol • GO:0007243 intracellular signal transduction • adult feeding behavior • response to hypoxia • regulation of natural killer cell proliferation • eating behavior • GO:0032737 positive regulation of cytokine production • regulation of cytokine production involved in inflammatory response • regulation of nitric-oxide synthase activity • response to activity • cellular response to leptin stimulus • regulation of cell cycle • regulation of natural killer cell mediated cytotoxicity • positive regulation of fat cell apoptotic process • positive regulation of cell population proliferation • regulation of lipoprotein lipid oxidation • positive regulation of phosphatidylinositol 3-kinase signaling • GO:0072468 Transdukcija signala • regulation of bone remodeling • lipid metabolism • negative regulation of appetite by leptin-mediated signaling pathway • interleukin-12 production • positive regulation of tumor necrosis factor production • interleukin-6 production • response to insulin • tyrosine phosphorylation of STAT protein • Fagocitoza • energy reserve metabolic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • determination of adult lifespan • regulation of lipid biosynthetic process • positive regulation of cold-induced thermogenesis • aorta development • GO:0048552 regulation of catalytic activity • elastin metabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3952	16846
Ensembl	ENSG00000174697	ENSMUSG00000059201
UniProt	P41159	P41160
RefSeq (mRNK)	NM_000230	NM_008493
RefSeq (bjelančevina)	NP_000221	NP_032519
Lokacija (UCSC)	Chr 7: 128.24 – 128.26 Mb	Chr 6: 29.06 – 29.07 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Leptin (grč. λεπτός - leptos = tanak) je proteinski hormon sa 16 kDa. Učestvuje u regulaciji unosa i potrošnje energije, putem uvećavanja apetita i metabolizma. To je jedan od najvažnijih hormona adipoznog porijekla.^[5] Gen Ob(Lep) (latinskiobese - gojazan) kod čovjeka je na hromosomu 7.^[6]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000174697 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000059201 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Brennan AM, Mantzoros CS (2006). "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications". Nat Clin Pract Endocrinol Metab. 2 (6): 318–27. doi:10.1038/ncpendmet0196. PMID 16932309.
6. ^ GreGreen ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC Jr, Leibel RL, Weissenbach J, Friedman JM (1995). "The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7". Genome Res. 5 (1): 5–12. doi:10.1101/gr.5.1.5. PMID 8717050.CS1 održavanje: više imena: authors list (link)