MMP7

MMP7
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1MMQ, 1MMR, 2MZE, 2DDY, 2Y6C, 2MZH, 1MMP, 2Y6D
Identifikatori
Aliasi	MMP7
Vanjski ID-jevi	OMIM: 178990 MGI: 103189 HomoloGene: 37619 GeneCards: MMP7
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q22.2 Početak 102,520,508 bp[1] Kraj 102,530,750 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9 A1|9 2.46 cM Početak 7,692,091 bp[2] Kraj 7,699,586 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • heparin binding • vezivanje iona cinka • vezivanje iona metala • GO:0070122 peptidase activity • metalloendopeptidase activity • hydrolase activity • serine-type endopeptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • metallopeptidase activity Ćelijska komponenta • GO:0005578 Vanćelijski matriks • extracellular region • cell surface • Egzosom • Vanćelijsko Biološki proces • maternal process involved in female pregnancy • estrous cycle • GO:0010260 starenje • extracellular matrix disassembly • cellular response to mechanical stimulus • response to nutrient levels • collagen catabolic process • Proteoliza • antibacterial peptide secretion • extracellular matrix organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4316	17393
Ensembl	ENSG00000137673	ENSMUSG00000018623
UniProt	P09237	Q10738 Q3UN27
RefSeq (mRNK)	NM_002423	NM_010810 NM_001319986
RefSeq (bjelančevina)	NP_002414	NP_001306915 NP_034940
Lokacija (UCSC)	Chr 11: 102.52 – 102.53 Mb	Chr 9: 7.69 – 7.7 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Matrilizin poznat i kao matriksna metaloproteinaza-7 (MMP-7), pumpna-1 proteaza (PUMP-1) ili maternična metaloproteinaza je enzim koji je kod ljudi kodiran genom MMP7.^[5] Enzim (EC 3.4.24.23) bio je poznat i kao matrin, pretpostavljena (ili punktirana) metaloproteinaza-1, metaloproteinazna matrična pumpa 1, proteinaza PUMP-1, PUMP, metaloproteinazna pumpa-1, navodna metaloproteinaza, MMP).^[6][7][8][9]

Matrilizin su otkrili Sellers i Woessner u maternici pacova 1988.^[10] Komplementarnu DNK (cDNK) ljidskog MMP7 izolirali su godine pomoću Muller et al, 1988..^[11] MMP7 je član porodice matriksnih metaloproteinaza (MMP) koja se sastoji od strukturno srodnih endopeptidaza zavisnih od cinka. Primarna uloga cijepanog/aktiviranog MMP7 je razgradnja vanćelijskog matriksa, razgradnjom makromolekula, uključujući kazein, tip I, II, IV i V želatine, fibronektin i proteoglikan.^[11][12]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137673 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000018623 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Knox JD, Boreham DR, Walker JA, Morrison DP, Matrisian LM, Nagle RB, Bowden GT (Jan 1997). "Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22". Cytogenet Cell Genet. 72 (2–3): 179–82. doi:10.1159/000134181. PMID 8978768.
6. ^ Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (juli 1988). "The collagenase gene family in humans consists of at least four members". The Biochemical Journal. 253 (1): 187–92. doi:10.1042/bj2530187. PMC 1149273. PMID 2844164.
7. ^ Woessner JF, Taplin CJ (novembar 1988). "Purification and properties of a small latent matrix metalloproteinase of the rat uterus". The Journal of Biological Chemistry. 263 (32): 16918–25. PMID 3182822.
8. ^ Quantin B, Murphy G, Breathnach R (juni 1989). "Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members". Biochemistry. 28 (13): 5327–34. doi:10.1021/bi00439a004. PMID 2550050.
9. ^ Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M (decembar 1990). "Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line". Cancer Research. 50 (24): 7758–64. PMID 2253219.
10. ^ Woessner JF, Taplin CJ (novembar 1988). "Purification and properties of a small latent matrix metalloproteinase of the rat uterus". J. Biol. Chem. 263 (32): 16918–25. doi:10.1016/S0021-9258(18)37479-9. PMID 3182822.
11. ^ ^{a b} Parks WC, Mecham RP (1988). "Matrix Metalloproteinases". 263. San Diego: Academic. journal zahtijeva |journal= (pomoć)
12. ^ Yokoyama Y, Grünebach F, Schmidt SM, Heine A, Häntschel M, Stevanovic S, Rammensee HG, Brossart P (2008). "Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells". Clin. Cancer Res. 14 (17): 5503–11. doi:10.1158/1078-0432.CCR-07-4041. PMID 18765542.