NOD2

NOD2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 5IRL, 5IRM, 5IRN
Identifikatori
Aliasi	NOD2
Vanjski ID-jevi	OMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek)[1] Bend 16q12.1 Početak 50,693,588 bp[1] Kraj 50,734,041 bp[1]
Lokacija gena (miš) Hrom. Hromosom 8 (miš)[2] Bend 8|8 C3 Početak 89,373,943 bp[2] Kraj 89,415,102 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • Hsp90 protein binding • nucleotide binding • Hsp70 protein binding • GO:0001948, GO:0016582 vezivanje za proteine • peptidoglycan binding • vezivanje enzima • actin binding • CARD domain binding • ATP binding • protein kinase binding • muramyl dipeptide binding • GO:0032403 protein-containing complex binding Ćelijska komponenta • citoplazma • citosol • Vezikula • membrana • ćelijska membrana • cell surface • basolateral plasma membrane • COP9 signalosome • citoskelet • Golđijev aparat • mitohondrija • GO:0009327 makromolekulani kompleks Biološki proces • positive regulation of prostaglandin-endoperoxide synthase activity • regulation of apoptotic process • defense response • detection of biotic stimulus • cytokine production involved in immune response • positive regulation of cytokine production involved in inflammatory response • GO:0007243 intracellular signal transduction • detection of muramyl dipeptide • positive regulation of interleukin-10 production • positive regulation of epithelial cell proliferation • immune system process • GO:1900490 positive regulation of oxidoreductase activity • response to muramyl dipeptide • positive regulation of prostaglandin-E synthase activity • positive regulation of JNK cascade • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of NIK/NF-kappaB signaling • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of gamma-delta T cell activation • cellular response to muramyl dipeptide • JNK cascade • negative regulation of macrophage apoptotic process • positive regulation of dendritic cell antigen processing and presentation • nucleotide-binding oligomerization domain containing 2 signaling pathway • maintenance of gastrointestinal epithelium • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-8 production • detection of bacterium • positive regulation of interleukin-1 beta production • regulation of inflammatory response • positive regulation of interleukin-6 production • protein complex oligomerization • positive regulation of tumor necrosis factor production • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of B cell activation • positive regulation of interleukin-17 production • positive regulation of type 2 immune response • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of stress-activated MAPK cascade • positive regulation of Notch signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:1904579 cellular response to organic cyclic compound • positive regulation of cell population proliferation • Urođeni imunski sistem • response to nutrient • positive regulation of dendritic cell cytokine production • positive regulation of protein K63-linked ubiquitination • cellular response to peptidoglycan • positive regulation of MAP kinase activity • interleukin-1-mediated signaling pathway • cellular response to lipopolysaccharide Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	64127	257632
Ensembl	ENSG00000167207	ENSMUSG00000055994
UniProt	Q9HC29	Q80SY9
RefSeq (mRNK)	NM_001293557 NM_022162 NM_001370466	NM_145857
RefSeq (bjelančevina)	NP_001280486 NP_071445 NP_001357395	NP_665856
Lokacija (UCSC)	Chr 16: 50.69 – 50.73 Mb	Chr 8: 89.37 – 89.42 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein 2 sa nukleotid-vezujućim domenom oligomerizacije (NOD2), znan i kao protein 15 sa domenom regrotacije kaspaze (CARD15) ili protein 1 upalne bolesti crijeva (IBD1), jest protein koji je kod ljudi kodiran genom NOD2 sa p kraka hromosoma 16.^[5][6] NOD2 ima važnu ulogu u imunskom sistemu. Prepoznaje bakterijske molekule (peptidoglikane) i stimulira imunsku reakciju.^[7]

NOD2 je unutarćelijski receptor prepoznavanja uzorka, koji je po strukturi sličan rezistentnim proteinima biljaka i prepoznaje molekule koji sadrže specifičnu strukturu zvanu muramil-dipeptid (MDP) koja se nalazi u određenim bakterijama.^[8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000167207 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000055994 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gilberts EC, Greenstein AJ, Katsel P, Harpaz N, Greenstein RJ (Dec 1994). "Molecular evidence for two forms of Crohn disease". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12721–4. Bibcode:1994PNAS...9112721G. doi:10.1073/pnas.91.26.12721. PMC 45511. PMID 7809109.
6. ^ Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G (Feb 1996). "Mapping of a susceptibility locus for Crohn's disease on chromosome 16". Nature. 379 (6568): 821–3. Bibcode:1996Natur.379..821H. doi:10.1038/379821a0. PMID 8587604. S2CID 4311407.
7. ^ Mahla RS, Reddy MC, Prasad DV, Kumar H (septembar 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.
8. ^ Kufer TA, Banks DJ, Philpott DJ (Aug 2006). "Innate immune sensing of microbes by Nod proteins". Annals of the New York Academy of Sciences. 1072 (1): 19–27. Bibcode:2006NYASA1072...19K. doi:10.1196/annals.1326.020. PMID 17057187. S2CID 20217610.