NOTCH3

NOTCH3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4ZLP, 5CZX, 5CZV
Identifikatori
Aliasi	NOTCH3
Vanjski ID-jevi	OMIM: 600276 MGI: 99460 HomoloGene: 376 GeneCards: NOTCH3
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19p13.12 Početak 15,159,038 bp[1] Kraj 15,200,995 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 B1|17 17.37 cM Početak 32,339,794 bp[2] Kraj 32,385,826 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje enzima • cadherin binding • vezivanje identičnih proteina • signaling receptor activity Ćelijska komponenta • integral component of membrane • endoplasmic reticulum membrane • membrana • Golđijeva membrana • receptor complex • ćelijska membrana • nukleoplazma • extracellular region • actin cytoskeleton • jedro • citosol • cell surface Biološki proces • Notch signaling pathway • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • negative regulation of neuron differentiation • negative regulation of cell differentiation • glomerular capillary formation • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • multicellular organism development • artery morphogenesis • forebrain development • neuron fate commitment • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of smooth muscle cell proliferation • GO:0090343, GO:0090342 regulation of developmental process • positive regulation of transcription of Notch receptor target • Notch receptor processing, ligand-dependent • negative regulation of Notch signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4854	18131
Ensembl	ENSG00000074181	ENSMUSG00000038146
UniProt	Q9UM47	Q61982
RefSeq (mRNK)	NM_000435	NM_008716
RefSeq (bjelančevina)	NP_000426	NP_032742
Lokacija (UCSC)	Chr 19: 15.16 – 15.2 Mb	Chr 17: 32.34 – 32.39 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Neurogeni lokus zareznog homologa proteina 3 je protein koji je kod ljudi kodiran genom NOTCH3.^[5][6]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000074181 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000038146 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (15. 9. 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
6. ^ "Entrez Gene: NOTCH3 Notch homolog 3 (Drosophila)".