Progesteronski receptor

Progesteronski receptor
Progesteronski receptor
Identifikatori
Simbol	PGR
Alt. simboli	NR3C3; PR Raspon ekspresije gena PGR
NCBI gen	5241
HGNC	8910
OMIM	607311
PDB	1A28 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8N, 3G8O, 3HQ5, 3KBA

Progesteronski receptor (PR), poznat kao NR3C3 ili potporodica 3 jedarnih receptora, grupa C, čjan 3, je protein koji se nalazi unutar ćelija. Aktivira ga steroidni hormon progesteron.

Kod ljudi, PR je kodiran jednim PGR genom koji se nalazi na dugom kraku hromosoma11, pozicija 11q22 ,^[1]^[2]^[3] ima dvije izoforme, PR-A i PR-B, koje se razlikuju u molekulskoj težini.^[4]^[5]^[6] PR-B je pozitivni regulator efekata progesterona, dok PR-A služi za antagonizaciju efekata PR-B.^[7]

^ Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (mart 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
^ Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (maj 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
^ ensembl.org, Gene: ESR1 (ENSG00000091831)
^ Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. doi:10.2741/1685. PMID 15970482.
^ Kase, Nathan G.; Speroff, Leon; Glass, Robert L. (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.
^ Fritz, Marc A.; Speroff, Leon (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.
^ Falcone, Tommaso; Hurd, William W. (22. 5. 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. str. 39–. ISBN 978-1-4614-6837-0.

[pmid3551956-1] Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (mart 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.

[pmid3472240-2] Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (maj 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.

[3] sembl.org, Gene: ESR1 (ENSG00000091831)

[pmid15970482-4] Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. doi:10.2741/1685. PMID 15970482.

[isbn0-683-30379-1-5] Kase, Nathan G.; Speroff, Leon; Glass, Robert L. (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.

[isbn0-7817-4795-3-6] Fritz, Marc A.; Speroff, Leon (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.

[FalconeHurd2013-7] Falcone, Tommaso; Hurd, William W. (22. 5. 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. str. 39–. ISBN 978-1-4614-6837-0.

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Progesteronski receptor

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