RAC1

RAC1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Identifikatori
Aliasi	RAC1
Vanjski ID-jevi	OMIM: 602048 MGI: 97845 HomoloGene: 69035 GeneCards: RAC1
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7p22.1 Početak 6,374,527 bp[1] Kraj 6,403,967 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 G2|5 82.22 cM Početak 143,489,389 bp[2] Kraj 143,513,791 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • histone deacetylase binding • Rho GDP-dissociation inhibitor binding • GTP-dependent protein binding • GO:0006184 GTPase activity • vezivanje enzima • GO:0001948, GO:0016582 vezivanje za proteine • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ATPase binding Ćelijska komponenta • citoplazma • citosol • membrana • focal adhesion • Melanosom • ruffle membrane • trans-Golđijeva mreža • jedro • projekcija ćelije • extrinsic component of plasma membrane • Egzosom • lamellipodium • early endosome membrane • ćelijska membrana • Mikronit • cytoplasmic ribonucleoprotein granule • endoplasmic reticulum membrane • Golđijeva membrana • phagocytic cup • GO:0016023 citoplazmatska vezikula • GO:0005578 Vanćelijski matriks • secretory granule membrane • dendritična kičma • recycling endosome membrane • postsynapse • glutamatergic synapse • ficolin-1-rich granule membrane Biološki proces • positive regulation of Rho protein signal transduction • regulation of respiratory burst • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • positive regulation of actin filament polymerization • regulation of neuron maturation • negative regulation of receptor-mediated endocytosis • platelet activation • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • phagocytosis, engulfment • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • Ćelijska proliferacija • ruffle assembly • lamellipodium assembly • dopaminergic neuron differentiation • cell-cell junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • ruffle organization • actin filament organization • cell motility • anatomical structure morphogenesis • bone resorption • response to wounding • protein localization to plasma membrane • inflammatory response • regulation of small GTPase mediated signal transduction • positive regulation of cell-substrate adhesion • G protein-coupled receptor signaling pathway • neuron projection morphogenesis • epithelial cell morphogenesis • dendrite morphogenesis • regulation of hydrogen peroxide metabolic process • engulfment of apoptotic cell • dendrite development • auditory receptor cell morphogenesis • hyperosmotic response • cerebral cortex GABAergic interneuron development • Hemotaksija • positive regulation of DNA replication • actin filament polymerization • Ćelijska adhezija • negative regulation of interleukin-23 production • homeostasis of number of cells within a tissue • cell-matrix adhesion • localization within membrane • actin cytoskeleton organization • regulation of cell size • anatomical structure arrangement • GO:0007243 intracellular signal transduction • regulation of cell migration • Endocitoza • ephrin receptor signaling pathway • T cell costimulation • Koagulacija (krv) • GO:0019049, GO:0030683 mitigation of host defenses by virus • synaptic transmission, GABAergic • mast cell chemotaxis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of substrate adhesion-dependent cell spreading • embryonic olfactory bulb interneuron precursor migration • cytoskeleton organization • cochlea morphogenesis • positive regulation of neutrophil chemotaxis • positive regulation of apoptotic process • regulation of cell morphogenesis • positive regulation of focal adhesion assembly • regulation of fibroblast migration • positive regulation of lamellipodium assembly • cerebral cortex radially oriented cell migration • Ćelijska migracija • semaphorin-plexin signaling pathway • positive regulation of stress fiber assembly • axon guidance • small GTPase mediated signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Wnt signaling pathway, planar cell polarity pathway • midbrain dopaminergic neuron differentiation • neuron migration • protein phosphorylation • Rho protein signal transduction • regulation of lamellipodium assembly • Rac protein signal transduction • cell projection assembly • positive regulation of microtubule polymerization • neutrophil degranulation • regulation of nitric oxide biosynthetic process • phosphatidylinositol phosphate biosynthetic process • hepatocyte growth factor receptor signaling pathway • regulation of stress fiber assembly • positive regulation of protein kinase B signaling • motor neuron axon guidance • regulation of neutrophil migration • positive regulation of insulin secretion involved in cellular response to glucose stimulus Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	5879	19353
Ensembl	ENSG00000136238	ENSMUSG00000001847
UniProt	P63000	P63001
RefSeq (mRNK)	NM_198829 NM_006908 NM_018890	NM_009007 NM_001347530
RefSeq (bjelančevina)	NP_008839 NP_061485	NP_001334459 NP_033033
Lokacija (UCSC)	Chr 7: 6.37 – 6.4 Mb	Chr 5: 143.49 – 143.51 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Rac1, poznat i kao Ras-srodni C3 supstrat botulinum toksina 1, je protein koji se nalazi u ljudskim ćelijama. Kodiran je genom RAC1.^[5][6] Ovaj gen može proizvesti razne alternativna prerade verzija proteina Rac1, za koje se čini da imaju različite funkcije.^[7]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000136238 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000001847 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (Oct 1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates". The Journal of Biological Chemistry. 264 (28): 16378–82. PMID 2674130.
6. ^ Jordan P, Brazåo R, Boavida MG, Gespach C, Chastre E (Nov 1999). "Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors". Oncogene. 18 (48): 6835–9. doi:10.1038/sj.onc.1203233. PMID 10597294.
7. ^ Zhou C, Licciulli S, Avila JL, Cho M, Troutman S, Jiang P, Kossenkov AV, Showe LC, Liu Q, Vachani A, Albelda SM, Kissil JL (Feb 2013). "The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis". Oncogene. 32 (7): 903–9. doi:10.1038/onc.2012.99. PMC 3384754. PMID 22430205.