Siderofor

Model karboksimikobaktina T na ionu Fe3+, prema PDB 1x8u

Siderofori (grč. σίδηρος – sídēros = gvožđe + φόρος – foros = nosač; nosač gvožđa) su mala, visoko afinitetna gvožđem-helirani spojevi koje izlučuju mikroorganizmi poput bakterija i gljiva i služe prvenstveno za transport gvožđaa preko ćelijskih membrana,^[2]^[3]^[4]^[5] iako se sada procjenjuje širi raspon funkcija siderofora^[6] Siderofori su među najjačim poznatim agensima za vezanje Fe³⁺.

^ Hossain MB, Eng-Wilmot DL, Loghry RA, an der Helm D (1980). "Circular Dichroism, Crystal Structure, and Absolute Configuration of the Siderophore Ferric N,N',N"-Triacetylfusarinine, FeC₃₉H₅₇N₆O₁₅". Journal of the American Chemical Society. 102 (18): 5766–5773. doi:10.1021/ja00538a012.
^ Neilands JB (novembar 1995). "Siderophores: structure and function of microbial iron transport compounds". The Journal of Biological Chemistry. 270 (45): 26723–6. doi:10.1074/jbc.270.45.26723. PMID 7592901.
^ Hider RC, Kong X (maj 2010). "Chemistry and biology of siderophores". Natural Product Reports. 27 (5): 637–57. doi:10.1039/b906679a. PMID 20376388.
^ Crosa JH, Mey AR, Payne SM, ured. (2004). Iron Transport in Bacteria. ASM Press. ISBN 978-1-55581-292-8.
^ Cornelis P, Andrews SC, ured. (2010). Iron Uptake and Homeostasis in Microorganisms. Caister Academic Press. ISBN 978-1-904455-65-3.
^ Johnstone TC, Nolan EM (april 2015). "Beyond iron: non-classical biological functions of bacterial siderophores". Dalton Transactions. 44 (14): 6320–39. doi:10.1039/C4DT03559C. PMC 4375017. PMID 25764171.

[1] Hossain MB, Eng-Wilmot DL, Loghry RA, an der Helm D (1980). "Circular Dichroism, Crystal Structure, and Absolute Configuration of the Siderophore Ferric N,N',N"-Triacetylfusarinine, FeC₃₉H₅₇N₆O₁₅". Journal of the American Chemical Society. 102 (18): 5766–5773. doi:10.1021/ja00538a012.

[J._B._Neilands-2] Neilands JB (novembar 1995). "Siderophores: structure and function of microbial iron transport compounds". The Journal of Biological Chemistry. 270 (45): 26723–6. doi:10.1074/jbc.270.45.26723. PMID 7592901.

[R._C._Hider-3] Hider RC, Kong X (maj 2010). "Chemistry and biology of siderophores". Natural Product Reports. 27 (5): 637–57. doi:10.1039/b906679a. PMID 20376388.

[J._H._Crosa-4] Crosa JH, Mey AR, Payne SM, ured. (2004). Iron Transport in Bacteria. ASM Press. ISBN 978-1-55581-292-8.

[CornelisP-5] Cornelis P, Andrews SC, ured. (2010). Iron Uptake and Homeostasis in Microorganisms. Caister Academic Press. ISBN 978-1-904455-65-3.

[6] Johnstone TC, Nolan EM (april 2015). "Beyond iron: non-classical biological functions of bacterial siderophores". Dalton Transactions. 44 (14): 6320–39. doi:10.1039/C4DT03559C. PMC 4375017. PMID 25764171.

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Siderofor

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