Tirozin-hidroksilaza

Tirozin-hidroksilaza
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2XSN, 4J6S
Identifikatori
Aliasi	TH
Vanjski ID-jevi	OMIM: 191290 MGI: 98735 HomoloGene: 307 GeneCards: TH
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.5 Početak 2,163,929 bp[1] Kraj 2,171,815 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 F5|7 88.06 cM Početak 142,446,489 bp[2] Kraj 142,484,865 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • tetrahydrobiopterin binding • tyrosine 3-monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen • ferrous iron binding • oxygen binding • vezivanje iona metala • dopamine binding • vezivanje enzima • oxidoreductase activity • iron ion binding • ferric iron binding • GO:0001948, GO:0016582 vezivanje za proteine • amino acid binding • monooxygenase activity • protein domain specific binding Ćelijska komponenta • citoplazma • citosol • mitohondrija • neuron projection • cytoplasmic side of plasma membrane • jedro • Sinapsna vezikula • melanosome membrane • terminal bouton • perikaryon • Akson • soma • smooth endoplasmic reticulum • dendrit • cytoplasmic vesicle membrane • GO:0016023 citoplazmatska vezikula Biološki proces • regulation of heart contraction • response to salt stress • response to steroid hormone • response to amphetamine • isoquinoline alkaloid metabolic process • response to zinc ion • terpene metabolic process • Učenje • epinephrine biosynthetic process • synaptic transmission, dopaminergic • circadian sleep/wake cycle • multicellular organism aging • animal organ morphogenesis • response to growth factor • response to ethanol • cellular response to glucose stimulus • phthalate metabolic process • locomotory behavior • response to light stimulus • anatomical structure morphogenesis • response to nicotine • response to metal ion • Memorija • heart development • response to nutrient levels • embryonic camera-type eye morphogenesis • socijalno ponašanje • cellular response to manganese ion • response to ether • sphingolipid metabolic process • response to immobilization stress • norepinephrine biosynthetic process • kognitivna funkcija • dopamine biosynthetic process • response to corticosterone • cellular response to nicotine • cellular response to alkaloid • mating behavior • response to electrical stimulus • response to isolation stress • glycoside metabolic process • aromatic amino acid family metabolic process • response to lipopolysaccharide • cerebral cortex development • response to pyrethroid • pigmentation • phytoalexin metabolic process • response to herbicide • Vid • response to estradiol • response to hypoxia • GO:1904578 response to organic cyclic compound • eating behavior • cellular response to growth factor stimulus • heart morphogenesis • response to water deprivation • catecholamine biosynthetic process • neurotransmitter biosynthetic process • response to peptide hormone • sluh • response to activity • fatty acid metabolic process • eye photoreceptor cell development • response to insecticide • dopamine biosynthetic process from tyrosine • aminergic neurotransmitter loading into synaptic vesicle Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7054	21823
Ensembl	ENSG00000180176	ENSMUSG00000000214
UniProt	P07101 P78428	P24529
RefSeq (mRNK)	NM_000360 NM_199292 NM_199293	NM_009377
RefSeq (bjelančevina)	NP_000351 NP_954986 NP_954987 NP_954986.2 NP_954987.2	NP_033403
Lokacija (UCSC)	Chr 11: 2.16 – 2.17 Mb	Chr 7: 142.45 – 142.48 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Tirozin-hidroksilaza ili tirozin 3-monooksigenaza je enzim koji je odgovoran za responsible kataliziranje konverzije aminkiseline L-tirozina u L-3,4-dihidroksifenilalanin (L-DOPA).^[5][6] To čini koristeći molekularni kisik (O₂), kao i gvožđe (Fe²⁺) i tetrahidrobiopterin kao kofaktore. L -DOPA je prekursor dopamina, koji je, pak, prekursor važnih neurotransmitera norepinefrina (noradrenalin) i epinefrina (adrenalin). Tirozin-hidroksilaza katalizira korak ograničavanja brzine u ovoj sintezi kateholamina. U ljudi je tirozin-hidroksilaza kodirana je TH genom,^[6] i enzimima u centralnom nervnom sistemu (CNS), perifernim simpatičkim neuronima i srži nadbubrežne žlijezde.^[6] Tirozin-hidroksilaza, fenilalanin hidroksilaza i triptofan hidroksilaza zajedno čine porodicu hidroksilaze aromatskih aminokiselina (AAAH).

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000180176 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000000214 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kaufman S (1995). "Tyrosine hydroxylase". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. 70. str. 103–220. doi:10.1002/9780470123164.ch3. ISBN 978-0-470-12316-4. PMID 8638482.
6. ^ ^{a b c} Nagatsu T (1995). "Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology". Essays in Biochemistry. 30: 15–35. PMID 8822146.