Tkivni faktor

F3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4M7L, 4Z6A, 4ZMA, 4YLQ, 2FLR
Identifikatori
Aliasi	F3
Vanjski ID-jevi	OMIM: 134390 MGI: 88381 HomoloGene: 1511 GeneCards: F3
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p21.3 Početak 94,529,173 bp[1] Kraj 94,541,759 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 G1|3 52.94 cM Početak 121,517,186 bp[2] Kraj 121,528,697 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • GO:0016518 cytokine receptor activity • phospholipid binding • serine-type endopeptidase activity • protease binding Ćelijska komponenta • membrana • GO:0005578 Vanćelijski matriks • intrinsic component of external side of plasma membrane • ćelijska membrana • extracellular region • Egzosom • cell surface • Vanćelijsko • serine-type peptidase complex • integral component of membrane • collagen-containing extracellular matrix Biološki proces • Hemostaza • positive regulation of protein kinase B signaling • positive regulation of endothelial cell proliferation • cytokine-mediated signaling pathway • positive regulation of cell migration • activation of blood coagulation via clotting cascade • positive regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of angiogenesis • blood coagulation, extrinsic pathway • activation of plasma proteins involved in acute inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of positive chemotaxis • Koagulacija (krv) • protein processing Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2152	14066
Ensembl	ENSG00000117525	ENSMUSG00000028128
UniProt	P13726	P20352
RefSeq (mRNK)	NM_001993 NM_001178096	NM_010171
RefSeq (bjelančevina)	NP_001171567 NP_001984	NP_034301
Lokacija (UCSC)	Chr 1: 94.53 – 94.54 Mb	Chr 3: 121.52 – 121.53 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Tkivni faktor, također zvani trombocitni tkivni faktor, faktor III, u CD142, je protein kodiran genom F3, prisutan u subendotelnom tkivu i leukocitima. Njegova uloga u procesu zgrušavanja je pokretanje stvaranja trombina iz zimogenskog protrombina. Tromboplastin definira kaskadu koja vodi do aktivacije faktora X—puta tkivnog faktora. Čineći to, zamijenio je prethodno imenovani vanjski put, kako bi se eliminirala dvosmislenost.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000117525 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000028128 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.