IGF1

IGF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Dynodwyr
Cyfenwau	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Dynodwyr allanol	OMIM: 147440 HomoloGene: 515 GeneCards: IGF1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • insulin receptor binding; • growth factor activity; • integrin binding; • GO:0001948, GO:0016582 protein binding; • insulin-like growth factor receptor binding;
Cydrannau o'r gell	• extracellular region; • exocytic vesicle; • insulin-like growth factor binding protein complex; • platelet alpha granule lumen; • insulin-like growth factor ternary complex; • alphav-beta3 integrin-IGF-1-IGF1R complex; • Cellbilen; • extracellular space;
Prosesau biolegol	• positive regulation of transcription regulatory region DNA binding; • skeletal system development; • positive regulation of glucose import; • muscle organ development; • positive regulation of Ras protein signal transduction; • response to heat; • positive regulation of cardiac muscle hypertrophy; • positive regulation of smooth muscle cell migration; • DNA replication; • positive regulation of insulin-like growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • positive regulation of DNA binding; • Ras protein signal transduction; • cell population proliferation; • positive regulation of mitotic nuclear division; • positive regulation of trophectodermal cell proliferation; • positive regulation of glycogen biosynthetic process; • positive regulation of fibroblast proliferation; • ERK1 and ERK2 cascade; • negative regulation of extrinsic apoptotic signaling pathway; • cell activation; • negative regulation of oocyte development; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • bone mineralization involved in bone maturation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of MAPK cascade; • proteoglycan biosynthetic process; • positive regulation of activated T cell proliferation; • positive regulation of epithelial cell proliferation; • negative regulation of release of cytochrome c from mitochondria; • protein stabilization; • myotube cell development; • positive regulation of DNA replication; • myoblast proliferation; • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; • positive regulation of protein secretion; • positive regulation of glycoprotein biosynthetic process; • regulation of gene expression; • phosphatidylinositol-mediated signaling; • positive regulation of smooth muscle cell proliferation; • Hypertrofedd cyhyrol; • protein kinase B signaling; • regulation of multicellular organism growth; • positive regulation of cell migration; • platelet degranulation; • positive regulation of calcineurin-NFAT signaling cascade; • positive regulation of phosphatidylinositol 3-kinase signaling; • myoblast differentiation; • glycolate metabolic process; • positive regulation of glycolytic process; • negative regulation of smooth muscle cell apoptotic process; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of cell population proliferation; • positive regulation of osteoblast differentiation; • activation of protein kinase B activity; • insulin-like growth factor receptor signaling pathway; • negative regulation of apoptotic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • GO:1901313 positive regulation of gene expression; • negative regulation of gene expression; • cellular response to amyloid-beta; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of vascular associated smooth muscle cell apoptotic process; • negative regulation of interleukin-1 beta production; • negative regulation of tumor necrosis factor production; • negative regulation of neuroinflammatory response; • negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologau
	3479
	n/a
	ENSG00000017427
	n/a
	P05019
	n/a
	NM_000618; NM_001111283; NM_001111284; NM_001111285
	n/a
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF1 yw IGF1 a elwir hefyd yn Insulin like growth factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q23.2.^[2]

[1] "Human PubMed Reference:".

[2] IGF1 - Cronfa NCBI

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[2]

IGF1

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