ACACA

ACACA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YL2, 3COJ, 4ASI
Identifiers
Aliases	ACACA, ACAC, ACACAD, ACC, ACC1, ACCA, acetyl-CoA carboxylase alpha, ACACalpha, Acac1, hACC1, ACCalpha
External IDs	OMIM: 200350; MGI: 108451; HomoloGene: 31015; GeneCards: ACACA; OMA:ACACA - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	37,406,836 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,292,477 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus callosum; ; ventricular zone; ; superior frontal gyrus; ; right adrenal cortex; ; prefrontal cortex; ; right frontal lobe; ; prostate; ; sural nerve; ; dorsolateral prefrontal cortex;
	Top expressed in
	brown adipose tissue; ; mammary gland; ; white adipose tissue; ; subcutaneous adipose tissue; ; mesenteric lymph nodes; ; intercostal muscle; ; aorta; ; parotid gland; ; otolith organ; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; metal ion binding; biotin carboxylase activity; ligase activity; protein binding; catalytic activity; ATP binding; identical protein binding; acetyl-CoA carboxylase complex; acetyl-CoA carboxylase activity;
Cellular component	actin cytoskeleton; fibrillar center; cytoplasm; cytosol;
Biological process	carnitine shuttle; malonyl-CoA biosynthetic process; lipid metabolism; fatty acid metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; tissue homeostasis; acetyl-CoA metabolic process; lipid homeostasis; metabolism; positive regulation of cellular metabolic process; protein homotetramerization; regulation of cholesterol biosynthetic process; fatty-acyl-CoA biosynthetic process; protein metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	31
	107476
	ENSG00000278540; ENSG00000275176
	ENSMUSG00000020532
	Q13085
	Q5SWU9
NM_000664; NM_198834; NM_198835; NM_198836; NM_198837;
	NM_198838; NM_198839
	NM_133360
	NP_942131; NP_942133; NP_942134; NP_942135; NP_942136
	NP_579938
	Wikidata
View/Edit Human	View/Edit Mouse

Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene.^[5]^[6]

^ ^a ^b ^c ENSG00000275176 GRCh38: Ensembl release 89: ENSG00000278540, ENSG00000275176 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020532 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: acetyl-Coenzyme A carboxylase alpha".
^ Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ (April 1995). "Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms". Proceedings of the National Academy of Sciences of the United States of America. 92 (9): 4011–5. Bibcode:1995PNAS...92.4011A. doi:10.1073/pnas.92.9.4011. PMC 42092. PMID 7732023.

[refGRCh38Ensembl-1] ENSG00000275176 GRCh38: Ensembl release 89: ENSG00000278540, ENSG00000275176 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020532 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: acetyl-Coenzyme A carboxylase alpha".

[pmid7732023-6] Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ (April 1995). "Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms". Proceedings of the National Academy of Sciences of the United States of America. 92 (9): 4011–5. Bibcode:1995PNAS...92.4011A. doi:10.1073/pnas.92.9.4011. PMC 42092. PMID 7732023.

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ACACA

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