Back مثبط إستيراز الأسيتيل كولين Arabic Inhibidor de la acetilcolinesterasa Spanish مهارکننده استیلکولین استراز Persian Inhibidor da acetilcolinesterase Galician מעכבי אצטילכולין אסטראז HE Inibitore dell'acetilcolinesterasi Italian アセチルコリンエステラーゼ阻害剤 Japanese 아세틸콜린에스터레이스 억제제 Korean Inibidor da acetilcolinesterase Portuguese Ингибиторы ацетилхолинэстеразы Russian
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors,[1] inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate,[2] thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors.[2] Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors.[2] Acetylcholinesterase is the primary member of the cholinesterase enzyme family.[3]
Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).[4][5]
- ^ "Medications for treating people with dementia" (PDF). Retrieved 1 January 2021.
- ^ a b c English, Brett A.; Webster, Andrew A. (2012). "Acetylcholinesterase and its Inhibitors". Primer on the Autonomic Nervous System. Elsevier. pp. 631–633. doi:10.1016/b978-0-12-386525-0.00132-3. ISBN 978-0-12-386525-0.
- ^ Seth (2009-11-18). "23". Textbook Of Pharmacology. Elsevier India. p. III.87. ISBN 978-8131211588.
Anaesthesia: Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia. 5. Genitourinary system: It may ...
- ^ Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM (May 2013). "Acetylcholinesterase inhibitors: pharmacology and toxicology". Current Neuropharmacology. 11 (3). Bentham Science Publishers Ltd.: 315–35. doi:10.2174/1570159x11311030006. PMC 3648782. PMID 24179466.
- ^ McGleenon BM, Dynan KB, Passmore AP (October 1999). "Acetylcholinesterase inhibitors in Alzheimer's disease". British Journal of Clinical Pharmacology. 48 (4): 471–80. doi:10.1046/j.1365-2125.1999.00026.x. PMC 2014378. PMID 10583015.