Back أمينوفيلين Arabic Aminofilin Azerbaijani آمینوفیلین AZB Aminoffylin Welsh Aminophyllin German Αμινοφυλλίνη Greek Aminofilina Spanish آمینوفیلین Persian Aminofylliini Finnish Aminofilin ID
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| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a601015 |
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| Routes of administration | By mouth, intravenous therapy (IV) |
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| Pharmacokinetic data | |
| Protein binding | 60% |
| Elimination half-life | 7–9 hours |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.005.696 |
| Chemical and physical data | |
| Formula | C16H24N10O4 |
| Molar mass | 420.434 g·mol−1 |
| 3D model (JSmol) | |
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Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate.[2]
Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of airway obstruction from asthma or COPD. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.[3]
- ^ "FDA-Approved Drugs Abbreviated New Drug Application (ANDA): 087242". fda.gov. October 26, 1983. Retrieved December 2, 2023.
- ^ "Aminophylline Professional Monograph". Drugs.com.
- ^ Mader TJ, Smithline HA, Durkin L, Scriver G (March 2003). "A randomized controlled trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest". Academic Emergency Medicine. 10 (3): 192–197. doi:10.1197/aemj.10.3.192. PMID 12615581.