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Antonio de Leyva, Duke of Terranova, Prince of Ascoli, Count of Monza (1480–1536) was a Spanish general during the Italian Wars. During the Italian War of 1521, he commanded Pavia during the siege of the city by Francis I of France, and took part in the Battle of Pavia in 1525. After the death of Fernando d'Ávalos, Marquis of Pescara, he held further commands in Italy during the War of the League of Cognac and finally died shortly after attempting an invasion of Provence.