The Apostolic Nunciature to Guinea-Bissau is an ecclesiastical office of the Catholic Church in Guinea-Bissau. It is a diplomatic post of the Holy See, whose representative is called the Apostolic Nuncio with the rank of an ambassador. The title Apostolic Nuncio to Guinea-Bissau is held by the prelate appointed Apostolic Nuncio to Senegal; he resides in Senegal.