Charles Edward Stuart (1720–1788) was the 18th century claimant to the title 'Prince of Wales' also known as Bonnie Prince Charlie.
Charles Edward Stuart may also refer to:
- Charles Edward Stuart, Count Roehenstart (c. 1784 – 1854), the aforementioned pretender's illegitimate grandson
- Charles E. Stuart (1810–1887), Michigan politician and US senator
- Charles E. Stuart (Virginia politician) (1850–1889)