Clodius may refer to:
- several ancient Romans, particularly the tribune Publius Clodius Pulcher; see Clodius
- Frederick Clod, last name also given as Clodius, 17th-century alchemist
- Gustav Clodius (1866–1944), German pastor and ornithologist
- Karl Clodius, a German diplomat during World War II; known for negotiating the "Clodius agreement" with Turkey
- Robert Clodius, an American educator
- Parnassius clodius, a butterfly