Count of Santa Cruz (in Portuguese Conde de Santa Cruz) was a Portuguese title of nobility created by a royal decree of King Philip II of Portugal, also known as Philip III of Spain, dated from October 3, 1593, and granted to Francisco de Mascarenhas (1530-1608), nephew of Dom Pedro de Mascarenhas, 6th Viceroy of Portuguese India.
Through a remarkable marriage policy, this family inherited several other titles and estates, such as Marquess of Gouveia in 1686, and Duke of Aveiro in 1745.