Cyclin-dependent kinase 4

CDK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Identifiers
Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
External IDs	OMIM: 123829; MGI: 88357; HomoloGene: 55429; GeneCards: CDK4; OMA:CDK4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,747,727 bp[1] End 57,756,013 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone stromal cell of endometrium right adrenal gland right ovary smooth muscle tissue right adrenal cortex left ovary left adrenal gland left adrenal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding ATP binding cyclin binding cyclin-dependent protein serine/threonine kinase activity protein-containing complex binding Cellular component cytoplasm cytosol cyclin-dependent protein kinase holoenzyme complex nuclear membrane membrane transcription regulator complex bicellular tight junction nucleoplasm nucleolus perinuclear region of cytoplasm chromatin nucleus cyclin D2-CDK4 complex protein-containing complex Biological process phosphorylation response to testosterone positive regulation of fibroblast proliferation response to hyperoxia positive regulation of translation regulation of cell cycle cell division protein phosphorylation lens development in camera-type eye regulation of cell population proliferation response to lead ion circadian rhythm animal organ regeneration positive regulation of cell population proliferation positive regulation of cell size positive regulation of apoptotic process regulation of gene expression cell cycle positive regulation of G2/M transition of mitotic cell cycle response to toxic substance positive regulation of cell cycle signal transduction multicellular organism development response to organic substance cellular response to insulin stimulus regulation of multicellular organism growth regulation of insulin receptor signaling pathway regulation of lipid biosynthetic process regulation of lipid catabolic process adipose tissue development cellular response to lipopolysaccharide cellular response to interleukin-4 cellular response to phorbol 13-acetate 12-myristate cellular response to ionomycin transcription initiation from RNA polymerase II promoter G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1019 12567 Ensembl ENSG00000135446 n/a UniProt P11802 P30285 RefSeq (mRNA) NM_052984 NM_000075 NM_009870 NM_001355005 RefSeq (protein) NP_000066 NP_034000 NP_001341934 Location (UCSC) Chr 12: 57.75 – 57.76 Mb n/a PubMed search [2] [3]
Wikidata
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Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle.^[4] CDK4 regulates the G1/S transition by contributing to the phosphorylation of retinoblastoma (RB) protein, which leads to the release of protein factors like E2F1 that promote S-phase progression.^[5] It is regulated by cyclins like cyclin D proteins, regulatory kinases, and cyclin kinase inhibitors (CKIs).^[5] Dysregulation of the CDK4 pathway is common in many cancers, and CDK4 is a new therapeutic target in cancer treatment.^[6]