Enzyme of the respiratory chain encoded by the mitochondrial genome
"Cox1" redirects here. Particularly in a medical context, this can also refer to
cyclooxygenase-1 .
Protein family
Location of the MT-CO1 gene in the human mitochondrial genome. MT-CO1 is one of the three cytochrome c oxidase subunit mitochondrial genes (orange boxes). Cytochrome c oxidase I (COX1 ) also known as mitochondrially encoded cytochrome c oxidase I (MT-CO1 ) is a protein that is encoded by the MT-CO1 gene in eukaryotes .[ 6] COX1 CO1 COI [ 7] cytochrome c oxidase complex. In humans, mutations in MT-CO1 have been associated with Leber's hereditary optic neuropathy (LHON), acquired idiopathic sideroblastic anemia , Complex IV deficiency, colorectal cancer , sensorineural deafness , and recurrent myoglobinuria .[ 8] [ 9] [ 10]
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