Back تلفيف مسنن Arabic Gyrus dentatus German Giro dentado Spanish Gyrus denté French Giro dentato Italian Gyrus dentatus Dutch Zakręt zębaty Polish Зубчатая извилина Russian Gyrus dentatus Swedish Зубчаста звивина Ukrainian
| Dentate gyrus | |
|---|---|
 Diagram of hippocampal regions. DG: Dentate gyrus. | |
 Coronal section of brain immediately in front of pons. (Label for "Gyrus dentatus" is at bottom center.) | |
| Details | |
| Part of | Temporal lobe |
| Artery | Posterior cerebral Anterior choroidal |
| Identifiers | |
| Latin | gyrus dentatus |
| MeSH | D018891 |
| NeuroNames | 179 |
| NeuroLex ID | birnlex_1178 |
| TA98 | A14.1.09.237 A14.1.09.339 |
| TA2 | 5521 |
| FMA | 61922 |
| Anatomical terms of neuroanatomy | |
The dentate gyrus (DG) is one of the subfields of the hippocampus, in the hippocampal formation. The hippocampal formation is located in the temporal lobe of the brain, and includes the hippocampus (including CA1 to CA4) subfields, and other subfields including the dentate gyrus, subiculum, and presubiculum.[1][2]
The dentate gyrus is part of the trisynaptic circuit, a neural circuit of the hippocampus, thought to contribute to the formation of new episodic memories,[3][4] the spontaneous exploration of novel environments[4] and other functions.[5] The dentate gyrus has toothlike projections from which it is named.[6]
The subgranular zone of the dentate gyrus is one of only two major sites of adult neurogenesis in the brain, and is found in many mammals.[7] The other main site is the subventricular zone in the ventricular system. Other sites may include the striatum and the cerebellum.[8][9] However, whether significant neurogenesis takes place in the adult human dentate gyrus has been a matter of debate.[10][11][12][2][13]
- ^ Meier, Kolja; Merseburg, Andrea; Isbrandt, Dirk; Marguet, Stephan Lawrence; Morellini, Fabio (9 September 2020). "Dentate Gyrus Sharp Waves, a Local Field Potential Correlate of Learning in the Dentate Gyrus of Mice". The Journal of Neuroscience. 40 (37): 7105–7118. doi:10.1523/JNEUROSCI.2275-19.2020. PMC 7480236.
- ^ a b Cite error: The named reference
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pmid17765709was invoked but never defined (see the help page). - ^ a b Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC (2009). "NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory". Neuron. 63 (5): 643–56. doi:10.1016/j.neuron.2009.08.014. PMID 19755107. S2CID 5321020.
- ^ Scharfman, Helen E., ed. (2011). The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications. Elsevier. ISBN 978-0-08-055175-3.[page needed]
- ^ Singh, Vishram (2014). Textbook of Anatomy Volume III (2nd ed.). RELX India. p. 403. ISBN 9788131237274.
- ^ Cameron HA, McKay RD (July 2001). "Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus". J. Comp. Neurol. 435 (4): 406–17. doi:10.1002/cne.1040. PMID 11406822. S2CID 15254735.
- ^ Ponti G, Peretto P, Bonfanti L (2008). "Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits". PLOS ONE. 3 (6): e2366. Bibcode:2008PLoSO...3.2366P. doi:10.1371/journal.pone.0002366. PMC 2396292. PMID 18523645.
- ^ Ernst, A; Alkass, K; Bernard, S; Salehpour, M; Perl, S; Tisdale, J; Possnert, G; Druid, H; Frisén, J (27 February 2014). "Neurogenesis in the striatum of the adult human brain". Cell. 156 (5): 1072–83. doi:10.1016/j.cell.2014.01.044. PMID 24561062.
- ^ Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. (March 2018). "Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults". Nature. 555 (7696): 377–381. Bibcode:2018Natur.555..377S. doi:10.1038/nature25975. PMC 6179355. PMID 29513649.
- ^ Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, et al. (April 2018). "Human Hippocampal Neurogenesis Persists throughout Aging". Cell Stem Cell. 22 (4): 589–599.e5. doi:10.1016/j.stem.2018.03.015. PMC 5957089. PMID 29625071.
- ^ Abbott, Louise C.; Nigussie, Fikru (January 2020). "Adult neurogenesis in the mammalian dentate gyrus". Anatomia, Histologia, Embryologia. 49 (1): 3–16. doi:10.1111/ahe.12496. PMID 31568602. S2CID 203622372.
- ^ Zhou, Yi; Su, Yijing; Li, Shiying; Kennedy, Benjamin C.; Zhang, Daniel Y.; Bond, Allison M.; Sun, Yusha; Jacob, Fadi; Lu, Lu; Hu, Peng; Viaene, Angela N.; Helbig, Ingo; Kessler, Sudha K.; Lucas, Timothy; Salinas, Ryan D. (July 2022). "Molecular landscapes of human hippocampal immature neurons across lifespan". Nature. 607 (7919): 527–533. doi:10.1038/s41586-022-04912-w. ISSN 1476-4687. PMC 9316413. PMID 35794479.