Back تكون العاج المعيب Arabic Dentinogenesis imperfecta German Dentinogénesis imperfecta Spanish डेनटिनोजेनेसिस इम्पर्फेक्टा Hindi Dentinogenesis imperfecta Hungarian Անկատար դենտինոգենեզ Armenian Dentinogenesi imperfetta Italian Dentinogenesis imperfecta Polish Dentinogênese imperfeita Portuguese Dentinogenesis imperfecta Turkish
| Dentinogenesis imperfecta | |
|---|---|
 | |
| Oral photographs from an individual with Dentinogenesis imperfecta | |
| Specialty | Dentistry  |
Dentinogenesis imperfecta (DI) is a genetic disorder of tooth development. It is inherited in an autosomal dominant pattern, as a result of mutations on chromosome 4q21, in the dentine sialophosphoprotein gene (DSPP).[1][2][3][4][5] It is one of the most frequently occurring autosomal dominant features in humans.[6] Dentinogenesis imperfecta affects an estimated 1 in 6,000-8,000 people.[7]
This condition can cause teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent, giving teeth an opalescent sheen.[2][3][8][5][9] Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss.[2][3][4][5][8] These problems can affect baby (primary/deciduous) teeth alone, or both baby teeth and adult (permanent) teeth, with the baby teeth usually more severely affected.[5][8]
Although genetic factors are the main contributor for the disease, any environmental or systemic upset that impedes calcification or metabolisation of calcium can also result in anomalous dentine.
- ^ Beattie ML, Kim JW, Gong SG, Murdoch-Kinch CA, Simmer JP, Hu JC (April 2006). "Phenotypic variation in dentinogenesis imperfecta/dentin dysplasia linked to 4q21". Journal of Dental Research. 85 (4): 329–333. doi:10.1177/154405910608500409. PMC 2238637. PMID 16567553.
- ^ a b c Barron MJ, McDonnell ST, Mackie I, Dixon MJ (November 2008). "Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia". Orphanet Journal of Rare Diseases. 3 (1): 31. doi:10.1186/1750-1172-3-31. PMC 2600777. PMID 19021896.
- ^ a b c de La Dure-Molla M, Philippe Fournier B, Berdal A (April 2015). "Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification". European Journal of Human Genetics. 23 (4): 445–451. doi:10.1038/ejhg.2014.159. PMC 4666581. PMID 25118030.
- ^ a b Soliman S, Meyer-Marcotty P, Hahn B, Halbleib K, Krastl G (September 2018). "Treatment of an Adolescent Patient with Dentinogenesis Imperfecta Using Indirect Composite Restorations - A Case Report and Literature Review". The Journal of Adhesive Dentistry. 20 (4): 345–354. doi:10.3290/j.jad.a40991. PMID 30206577.
- ^ a b c d Malmgren B, Norgren S (March 2002). "Dental aberrations in children and adolescents with osteogenesis imperfecta". Acta Odontologica Scandinavica. 60 (2): 65–71. doi:10.1080/000163502753509446. PMID 12020117. S2CID 110970.
- ^ Thotakura SR, Mah T, Srinivasan R, Takagi Y, Veis A, George A (March 2000). "The non-collagenous dentin matrix proteins are involved in dentinogenesis imperfecta type II (DGI-II)". Journal of Dental Research. 79 (3): 835–839. doi:10.1177/00220345000790030901. PMID 10765957. S2CID 38418321.
- ^ Witkop CJ (January 1975). "Hereditary defects of dentin". Dental Clinics of North America. 19 (1): 25–45. doi:10.1016/S0011-8532(22)00655-3. PMID 162890. S2CID 22518085.
- ^ a b c Ma MS, Najirad M, Taqi D, Retrouvey JM, Tamimi F, Dagdeviren D, et al. (March 2019). "Caries prevalence and experience in individuals with osteogenesis imperfecta: A cross-sectional multicenter study". Special Care in Dentistry. 39 (2): 214–219. doi:10.1111/scd.12368. PMC 6402806. PMID 30758072.
- ^ Cite error: The named reference
Bath-Balogh_2011was invoked but never defined (see the help page).