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E10, E 10 or E-10 may refer to:
- E10 fuel, see Common ethanol fuel mixtures#E10 or less, a mixture of 10% ethanol and 90% petrol
- Diabetes mellitus type 1 ICD-10 code
- Entertainment Software Rating Board: E10+, the symbol for Everyone 10+, indicating material that may not be suitable for those under 10
- E10 screw, a type of Edison screw
- Olympus E-10, a single-lens reflex camera digital camera from 2000
- Queen's Pawn Game, Encyclopaedia of Chess Openings code
- The 10 elected members of the United Nations Security Council
- E10 (Lie algebra), a mathematical structure