Eunice Caldwell Cowles (February 4, 1811 – September 10, 1903) was an American educator who influenced hundreds of women in the U.S. and abroad. She was the first associate of Mary Lyon in the opening of Mount Holyoke Seminary (now Mount Holyoke College). She had previously graduated under Lyon and Zilpah Grant from Ipswich Seminary (later known as, Ipswich Female Seminary) in 1829, where she was afterwards principal from 1844 to 1876.[1] She also served as the first principal of Wheaton Seminary (now Wheaton College). She was also affiliated with the Christian Woman's Board of Missions (C.W.B.M.), having co-founded the Essex North Branch and serving as its president.