Fenethylline

Fenethylline
INN: Fenetylline
Skeletal formula
Space-filling model of the captagon molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Legal status
Legal status
Identifiers
  • (RS)-1,3-dimethyl- 7-[2-(1-phenylpropan-2-ylamino)ethyl]purine- 2,6-dione
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.115.827 Edit this at Wikidata
Chemical and physical data
FormulaC18H23N5O2
Molar mass341.415 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=C2N(c1ncn(c1C(=O)N2C)CCNC(C)Cc3ccccc3)C
  • InChI=1S/C18H23N5O2/c1-13(11-14-7-5-4-6-8-14)19-9-10-23-12-20-16-15(23)17(24)22(3)18(25)21(16)2/h4-8,12-13,19H,9-11H2,1-3H3 checkY
  • Key:NMCHYWGKBADVMK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fenethylline (BAN, USAN) or fenetylline (INN) is a codrug of amphetamine and theophylline and so a mutual prodrug of both. It is also spelled phenethylline; other names for it are amphetaminoethyltheophylline and amfetyline. The drug was marketed for use as a psychostimulant under the brand names Captagon, Biocapton, and Fitton.[2][3] The name "Captagon" is often used generically to describe illicitly produced fenethylline.

Fenethylline is now illegal in most countries; it is produced primarily for illicit use, which takes place mainly in the Middle East, often as a stimulant for gunmen. The illicit global market for the drug was estimated in 2023 to be worth approximately US$57 billion.[4] Smuggling of Captagon became Syria's principal export, exceeding the total of all other exports under the Assad regime during the period from 2011 to 2024 of the Syrian Civil War in which it ruled Syria;[5] it was considered to be the world's largest producer of the drug, accounting for about 80% of the global supply.[6][7] A huge quantity of "Captagon", ready for clandestine export, was captured by anti-Assad forces that took control of Damascus in December 2024.[5]

  1. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  2. ^ Dictionary of Organic Compounds. CRC Press. 1996. pp. 3140–. ISBN 978-0-412-54090-5.
  3. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 431–. ISBN 978-3-88763-075-1.
  4. ^ Foreign, Commonwealth & Development Office and Lord (Tariq) Ahmad of Wimbledon (28 March 2023). "Tackling the illicit drug trade fuelling Assad's war machine". GOV.UK.
  5. ^ a b "Syrian rebels seize vast haul of banned drug captagon, country's largest export". The Guardian. Damascus. Agence France-Presse. 12 December 2024. Archived from the original on 13 December 2024.
  6. ^ Alkhaldi C (11 April 2023). "A little-known drug brought billions to Syria's coffers. Now it's a bargaining chip". CNN. Archived from the original on 17 May 2023.
  7. ^ "What is Captagon, the addictive drug mass-produced in Syria?". Al Jazeera News. 9 May 2023. Archived from the original on 5 June 2023.

From Wikipedia, the free encyclopedia · View on Wikipedia

Developed by Nelliwinne