Fraternal birth order and male sexual orientation

Fraternal birth order, also known as the older brother effect, has been correlated with male sexual orientation, with a significant volume of research finding that the more older brothers a male has from the same mother, the greater the probability he will have a homosexual orientation. Ray Blanchard and Anthony Bogaert first identified the association in the 1990s and named it the fraternal birth order effect. Scientists have attributed the effect to a prenatal biological mechanism, since the association is only present in men with older biological brothers, and not present among men with older step-brothers and adoptive brothers. The mechanism is thought to be a maternal immune response to male fetuses, whereby antibodies neutralize male Y-proteins thought to play a role in sexual differentiation during development. This would leave some regions of the brain associated with sexual orientation in the 'female typical' arrangement – or attracted to men.

The effect becomes stronger with each additional male pregnancy, with odds of the next son being homosexual increasing by 38–48%. This does not mean that all or most sons will be homosexual after several male pregnancies, but rather, the odds of having a homosexual son increase from approximately 2% for the first born son, to 3% for the second, 5% for the third and so on.[1][2] In a 2017 study; mothers with gay sons, particularly those with older brothers, had heightened levels of antibodies to the NLGN4Y Y-protein compared to mothers with heterosexual sons.[1][3]

It has generally been thought that this maternal response would not apply to first-born gay sons and that they may owe their orientation to other mechanisms.[3] However, mothers with no sons also showed antibodies to male cells, which may be a result of male miscarriages or abortion.[3][4]

  1. ^ a b Balthazart, Jacques (2018-01-09). "Fraternal birth order effect on sexual orientation explained". Proceedings of the National Academy of Sciences of the United States of America. 115 (2): 234–236. Bibcode:2018PNAS..115..234B. doi:10.1073/pnas.1719534115. ISSN 0027-8424. PMC 5777082. PMID 29259109.
  2. ^ Blanchard R (1997). "Birth order and sibling sex ratio in homosexual versus heterosexual males and females". Annual Review of Sex Research. 8: 27–67. doi:10.1080/10532528.1997.10559918. PMID 10051890.
  3. ^ a b c Bogaert, Anthony F.; Skorska, Malvina N.; Wang, Chao; Gabrie, José; MacNeil, Adam J.; Hoffarth, Mark R.; VanderLaan, Doug P.; Zucker, Kenneth J.; Blanchard, Ray (2018-01-09). "Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y". Proceedings of the National Academy of Sciences of the United States of America. 115 (2): 302–306. Bibcode:2018PNAS..115..302B. doi:10.1073/pnas.1705895114. ISSN 0027-8424. PMC 5777026. PMID 29229842.
  4. ^ Coghlan, Andy (December 2017). "We may know why younger brothers are more likely to be gay". New Scientist. Retrieved 2020-08-03.

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