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Gasparini is an Italian surname and may refer to:
- Francesco Gasparini (1668–1727), or simply "Gasparini," Italian composer
- Gaspare Gasparini (died 1590), Italian painter
- Graziano Gasparini (1924–2019), Venezuelan architect
- John Gasparini (fl. 1978–2009), former hockey coach and president of the United States Hockey League
- Marten Gasparini (born 1997), Italian baseball player
- Mitja Gasparini (born 1984), Slovenian volleyball player
- Quirino Gasparini (1721–1778), Italian composer
- Zulma Brandoni de Gasparini, Argentine palaeontologist