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George Klein may refer to:
- George Klein (inventor) (1904–1992), Canadian inventor
- George Klein (comics) (c. 1915 or 1920 – 1969), American comic book artist
- George Klein (biologist) (1925–2016), Hungarian-Swedish biologist and writer
- George Klein (physician), Canadian cardiologist
- George Klein (DJ) (1935–2019), disc jockey and television host
- George Klein (Canadian football) (1932–?), Canadian football player
- George S. Klein (1917–1971), American psychologist and psychoanalyst
- Adam Klein (swimmer) (George Klein IV, born 1988), American swimmer