Seven ships of the Royal Navy have been named HMS Melpomene after the Muse of Tragedy in ancient Greek mythology.
- HMS Melpomene (1794) was a 38-gun fifth-rate frigate captured in 1794 and sold in 1815 after service in the French Revolutionary and Napoleonic Wars.
- HMS Melpomene (1815) was a 38-gun French frigate launched in 1812 that the Royal Navy captured in 1815 and sold in 1821.
- HMS Melpomene (1857) was a screw frigate launched in 1857 and sold in 1875.
- HMS Melpomene (1888) was a Marathon-class light cruiser launched in 1888 and sold in 1905.
- HMS Melpomene was an Apollo-class protected cruiser launched in 1891 as HMS Indefatigable. She was renamed HMS Melpomone in 1910 and was sold in 1913.
- HMS Melpomene (1915) was a Medea-class destroyer, built for the Greek Navy as the Samos. She was purchased in 1914 and launched in 1915. She was broken up in 1921.
- HMS Melpomene was a minelayer, formerly the monitor HMS M31 launched in 1915. She was renamed HMS Melpomene in 1922 and HMS Menelaus in 1940, being broken up in 1948.