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Hamasien (Tigrinya: ሓማሴን) (Ge'ez ሓማሴን) was a historical province including and surrounding Asmara, part of modern Eritrea. In 1996 the province was divided and distributed largely to the modern Maekel region, with smaller parts being distributed amongst the Debub, Northern Red Sea, Gash-Barka, and Anseba regions.
Hamasien was located northwest of Akele Guzai and northeast of Seraye. Traditionally being the center of the Eritrean highlands, it is the locality of the city of Asmara (the capital of Eritrea).