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Hampden Coit DuBose (30 September 1845 in Darlington, South Carolina – 22 March 1910[1] in Suzhou) was a Presbyterian missionary in China with the American Presbyterian Mission (South) and founder of the Anti-Opium League in China. Rev. Dr. Hampden Coit DuBose was the son of Rev. Julius Jesse DuBose and Margaret Eliza Thompson, married Pauline McAlpine, daughter of Augustine Irving McAlpine and Martha Clisby and had seven children with her.[1]