Hideyo Noguchi

Hideyo Noguchi
野口 英世
Born(1876-11-09)November 9, 1876
DiedMay 21, 1928(1928-05-21) (aged 51)
Resting placeWoodlawn Cemetery, New York City, US
Known forsyphilis
Treponema pallidum
Scientific career
Fieldsbacteriology
Japanese name
Kanji野口 英世
Hiraganaのぐち ひでよ
Transcriptions
RomanizationNoguchi Hideyo

Hideyo Noguchi (野口 英世, Noguchi Hideyo, November 9, 1876 – May 21, 1928), also known as Seisaku Noguchi (野口 清作, Noguchi Seisaku), was a prominent Japanese bacteriologist most known for his work on syphilis at the Rockefeller Institute. Noguchi broadened the knowledge of the disease and diagnosis and long term understanding of neurosyphilis.[1]

Noguchi having discovered Treponema pallidum in the tissues of a paretic patient established the conclusive link between patients suffering from syphilis and the cause of paresis and tabes dorsalis. His discovery proved for the first time the homogeneity between a mental and physical disease through demonstrating that psychosis could be caused by an organic agent in patients suffering from late-stage syphilis. [2]

Before his work at the Rockefeller Institute, he pioneered the fields of immunology and serology under Simon Flexner at the University of Pennsylvania, creating the foundation for modern antivenoms. Later at the Rockefeller Institute, Noguchi developed the first effective serum used to treat Rocky Mountain Spotted Fever, previously a notoriously lethal disease.

Some of his work posthumously has been questioned. Noguchi's misidentification of yellow fever as a bacteria was not factual and his pure culture of syphilis, which was considered irreproducible, has been received with skepticism. His physical and mental health declined in his later years, possibly having undiagnosed neurosyphilis during his research. Eventually, Noguchi died during a trip to Africa in search for the cause of yellow fever, but he died of the same disease.

Noguchi's discoveries led him to gain international recognition and become one of the first Japanese scientists to gain global acclaim and accolades with his obituary being featured in The New York Times, granted numerous awards from foreign dignitaries, and nominated several times for a Nobel prize in medicine.[3][4]

  1. ^ Swaminathan, Srivatsan (May 30, 2024). "Hideyo Noguchi (1876–1928)". Arizona State University - Embryo Project Encyclopedia.
  2. ^ Plesset, Isabel (1980). Noguchi and his Patrons. Fairleigh Dickinson University Press. p. 130.
  3. ^ Cite error: The named reference nominationdb was invoked but never defined (see the help page).
  4. ^ "Dr. Noguchi is Dead, Martyr of Science". The New York Times. May 22, 1928.

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