Back إيفوسفامايد Arabic Iffosffamid Welsh Ifosfamid German Ιφωσφαμίδη Greek Ifosfamida Spanish ایفوسفامید Persian Ifosfamidi Finnish Ifosfamide French איפוספאמיד HE Իֆոսֆամիդ Armenian
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 (R)-(+)- and (S)-(−)-ifosfamide (top), (S)-(−)-ifosfamide (bottom) | |
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| Pronunciation | /aɪˈfɒsfəmaɪd/ |
| Trade names | Ifex, others |
| Other names | IFO, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a695023 |
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| Routes of administration | Intravenous |
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| Pharmacokinetic data | |
| Bioavailability | 100% |
| Metabolism | Liver |
| Elimination half-life | 60–80% in 72 hours |
| Excretion | Kidney |
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| ECHA InfoCard | 100.021.126 |
| Chemical and physical data | |
| Formula | C7H15Cl2N2O2P |
| Molar mass | 261.08 g·mol−1 |
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Ifosfamide, sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer.[3] This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer.[3] It is administered by injection into a vein.[3]
Common side effects include hair loss, vomiting, blood in the urine, infections, and kidney problems.[3] Other severe side effects include bone marrow suppression and decreased level of consciousness.[3] Use during pregnancy will likely result in harm to the baby.[3] Ifosfamide is in the alkylating agent and nitrogen mustard family of medications.[3][4] It works by disrupting the duplication of DNA and the creation of RNA.[3]
Ifosfamide was approved for medical use in the United States in 1987.[3] It is on the World Health Organization's List of Essential Medicines.[5]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ "Ifex Product information". Health Canada. 9 April 2001. Retrieved 17 February 2025.
- ^ a b c d e f g h i "Ifosfamide". The American Society of Health-System Pharmacists. Archived from the original on 7 May 2017. Retrieved 8 December 2016.
- ^ Dowd FJ, Johnson B, Mariotti A (2016). Pharmacology and Therapeutics for Dentistry (7th ed.). Elsevier Health Sciences. p. 533. ISBN 9780323445955. Archived from the original on 11 September 2017.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.