Iobenguane

Iobenguane
Clinical data
Trade names	Adreview, Azedra
Other names	meta-iodobenzylguanidine; mIBG, MIBG
License data	US DailyMed: Iobenguane;
Routes of; administration	Intravenous
ATC code	V09IX01 (WHO) (123I); V09IX02 (WHO) (131I, diagnostic); V10XA02 (WHO) (131I, therapeutic);
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-(3-iodobenzyl)guanidine;
CAS Number	80663-95-2 77679-27-7; 76924-93-1;
PubChem CID	60860; 135326;
DrugBank	DB06704 ;
ChemSpider	54847 ;
UNII	35MRW7B4AD; P2TH1XYZ84;
KEGG	D04559; D04560;
ChEBI	CHEBI:92769;
ChEMBL	ChEMBL818 ;
CompTox Dashboard (EPA)	DTXSID30228311 ;
Chemical and physical data
Formula	C8H10IN3
Molar mass	275.093 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC(=C1)I)CNC(=N)N;
	InChI InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12) ; Key:PDWUPXJEEYOOTR-UHFFFAOYSA-N ;
	(what is this?) (verify)

Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical.^[3] It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used in nuclear medicinal diagnostic and therapy techniques as well as in neuroendocrine chemotherapy treatments.

It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as pheochromocytomas and neuroblastomas.^[4] With iodine-131 it can also be used to treat tumor cells that take up and metabolize norepinephrine.

^ "Adreview- iobenguane i-123 injection". DailyMed. 10 March 2020. Retrieved 21 May 2022.
^ "Azedra- iobenguane i-131 injection, solution". DailyMed. 8 April 2021. Retrieved 21 May 2022.
^ Olecki E, Grant CN (December 2019). "MIBG in neuroblastoma diagnosis and treatment". Seminars in Pediatric Surgery. 28 (6): 150859. doi:10.1016/j.sempedsurg.2019.150859. PMID 31931960. S2CID 210191760.
^ Scarsbrook AF, Ganeshan A, Statham J, Thakker RV, Weaver A, Talbot D, et al. (2007). "Anatomic and functional imaging of metastatic carcinoid tumors". Radiographics. 27 (2): 455–477. doi:10.1148/rg.272065058. PMID 17374863.

[1] "Adreview- iobenguane i-123 injection". DailyMed. 10 March 2020. Retrieved 21 May 2022.

[2] "Azedra- iobenguane i-131 injection, solution". DailyMed. 8 April 2021. Retrieved 21 May 2022.

[3] Olecki E, Grant CN (December 2019). "MIBG in neuroblastoma diagnosis and treatment". Seminars in Pediatric Surgery. 28 (6): 150859. doi:10.1016/j.sempedsurg.2019.150859. PMID 31931960. S2CID 210191760.

[pmid17374863-4] Scarsbrook AF, Ganeshan A, Statham J, Thakker RV, Weaver A, Talbot D, et al. (2007). "Anatomic and functional imaging of metastatic carcinoid tumors". Radiographics. 27 (2): 455–477. doi:10.1148/rg.272065058. PMID 17374863.

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Iobenguane

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