Isaac Seneca | |
|---|---|
 Isaac Seneca | |
| Born | October 7, 1874 |
| Died | 1945 (aged 70–71) |
| Resting place | United Missions Cemetery, Erie County, New York |
| Alma mater | Carlisle Indian Industrial School |
| Known for | First Native American to be named a College Football All-American, 1899 |
| Spouse | Rose Frass (m. 1904) |
Isaac Seneca Jr. (October 7, 1874 – 1945) was an All-American football player for the Carlisle Indian Industrial School. He was selected as an All-American halfback on the 1899 College Football All-America Team. He was the first Carlisle player and the first American Indian to be selected as an All-American. He was born in 1874 on the Cattaraugus Reservation in New York.