John A. Macdonald was Canada's first Prime Minister
John Macdonald may also refer to:
- John MacDonald (Prince Edward Island politician) (1838–1905), former speaker of the Prince Edward Island assembly
- John Macdonald (Prince Edward Island politician) (1874–1948), Canadian member of parliament for King's, Prince Edward Island
- John Macdonald (Nova Scotia politician) (1883–1945), Conservative member for Richmond-West Cape Breton, Nova Scotia, Senator
- John A. MacDonald (Nova Scotia politician), Progressive Conservative provincial member
- Jack MacDonald (Hamilton politician) (1927–2010), businessman, journalist, and mayor of Hamilton, Ontario
- John McDonald (Nova Scotia politician) (1889–1962), Liberal senator from Nova Scotia