Kava consists of sterile cultivars clonally propagated from its wild ancestor, Piper wichmanii.[6] It originated in northern Vanuatu, where it was domesticated by farmers around 3,000 years ago through selective cultivation.[7] Historically, the beverage was made from fresh kava; preparation from dry kava emerged in response to the efforts of Christianmissionaries in the 18th and 19th centuries to prohibit the drinking of kava.[8]
Its active compounds are known as kavalactones.[9] Systematic reviews and meta-analyses conducted in the last decade have typically indicated a modest positive effect of kava on anxiety and Generalized Anxiety Disorder, though the evidence is mixed and further research is frequently recommended.[10][11][12][13][14][15]
Moderate consumption of kava in its traditional form, as a water-based suspension of kava roots, is considered by the World Health Organization to present an “acceptably low level of health risk.”[16] However, consumption of kava extracts produced with organic solvents or excessive amounts of low-quality kava products may be linked to an increased risk of adverse health outcomes, including liver injury.[16][17][18]
^Savage, K. M., Stough, C. K., Byrne, G. J., Scholey, A., Bousman, C., Murphy, J., Macdonald, P., Suo, C., Hughes, M., Thomas, S., Teschke, R., Xing, C., & Sarris, J. (2015). Kava for the treatment of generalised anxiety disorder (K-GAD): Study protocol for a randomised controlled trial. Trials, 16, 493. https://doi.org/10.1186/s13063-015-0986-5
^Barić, H., Đorđević, V., Cerovečki, I., & Trkulja, V. (2018). Complementary and alternative medicine treatments for generalized anxiety disorder: Systematic review and meta-analysis of randomized controlled trials. Advances in Therapy, 35(3), 261-288. https://doi.org/10.1007/s12325-018-0680-6
^Smith, K., & Leiras, C. (2018). The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. Complementary Therapies in Clinical Practice, 33, 107-117. https://doi.org/10.1016/j.ctcp.2018.09.003
^White, C. M. (2018). The pharmacology, pharmacokinetics, efficacy, and adverse events associated with kava. The Journal of Clinical Pharmacology, 58(11), 1396-1405. https://doi.org/10.1002/jcph.1263
^Sarris, J., et al. (2020). Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study. Australian & New Zealand Journal of Psychiatry, 54(3), 288-297. https://doi.org/10.1177/0004867419891246
^Kuchta K, Schmidt M, Nahrstedt A (1 December 2015). "German Kava Ban Lifted by Court: The Alleged Hepatotoxicity of Kava (Piper methysticum) as a Case of Ill-Defined Herbal Drug Identity, Lacking Quality Control, and Misguided Regulatory Politics". Planta Medica. 81 (18): 1647–1653. doi:10.1055/s-0035-1558295. ISSN1439-0221. PMID26695707. S2CID23708406.
^Showman AF, Baker JD, Linares C, et al. (2015). "Contemporary Pacific and Western perspectives on 'awa (Piper methysticum) toxicology". Fitoterapia. 100: 56–67. doi:10.1016/j.fitote.2014.11.012. PMID25464054.