Kissimmee is the name of several things in the U.S. state of Florida:
- Kissimmee, Florida (city, incorporated in 1883)
- Kissimmee City Street Railway
- Kissimmee Kreatures (arena football team)
- Kissimmee Utility Authority (local power and Internet provider)
- Kissimmee River
- Lake Kissimmee
- Kissimmee, Pennsylvania (town in Pennsylvania)