Kisspeptin

KISS1
Identifiers
Aliases	KISS1, HH13, KiSS-1, KiSS-1 metastasis-suppressor, KiSS-1 metastasis suppressor
External IDs	OMIM: 603286; MGI: 2663985; HomoloGene: 1701; GeneCards: KISS1; OMA:KISS1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	204,196,491 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	133,257,639 bp
RNA expression pattern
	Top expressed in
	placenta; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; nucleus accumbens; ; right testis; ; left testis; ; Pituitary Gland; ; putamen; ; mucosa of transverse colon; ; duodenum;
	Top expressed in
	periventricular zone of hypothalamus; ; arcuate nucleus; ; preoptic area; ; embryo; ; striatum of neuraxis; ; muscle of thigh; ; lung; ; conceptus; ; liver; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kisspeptin receptor binding;
Cellular component	extracellular region; apical plasma membrane; cytoplasm; soma; neuron projection; extracellular space;
Biological process	negative regulation of cell population proliferation; positive regulation of synaptic transmission; positive regulation of MAPK cascade; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of luteinizing hormone secretion; positive regulation of cytosolic calcium ion concentration; positive regulation of growth hormone secretion; cytoskeleton organization; generation of ovulation cycle rhythm; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3814
	280287
	ENSG00000170498
	ENSMUSG00000116158
	Q15726
	Q6Y4S4
	NM_002256
	NM_178260
	NP_002247
	NP_839991
	Wikidata
View/Edit Human	View/Edit Mouse

Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteins encoded by the KISS1 gene in humans. Kisspeptins are ligands of the G-protein coupled receptor, GPR54.^[5] Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis.^[6] Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research.^[7] Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitary triggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and humans. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170498 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000116158 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA (February 2005). "Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54". Proceedings of the National Academy of Sciences of the United States of America. 102 (5): 1761–6. Bibcode:2005PNAS..102.1761M. doi:10.1073/pnas.0409330102. PMC 545088. PMID 15665093.
^ Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (December 1996). "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene". Journal of the National Cancer Institute. 88 (23): 1731–7. doi:10.1093/jnci/88.23.1731. PMID 8944003.
^ Skorupskaite K, George JT, Anderson RA (2014). "The kisspeptin-GnRH pathway in human reproductive health and disease". Human Reproduction Update. 20 (4): 485–500. doi:10.1093/humupd/dmu009. PMC 4063702. PMID 24615662.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170498 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000116158 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15665093-5] Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA (February 2005). "Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54". Proceedings of the National Academy of Sciences of the United States of America. 102 (5): 1761–6. Bibcode:2005PNAS..102.1761M. doi:10.1073/pnas.0409330102. PMC 545088. PMID 15665093.

[Lee_1996-6] Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (December 1996). "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene". Journal of the National Cancer Institute. 88 (23): 1731–7. doi:10.1093/jnci/88.23.1731. PMID 8944003.

[SkorupskaiteGeorge2014-7] Skorupskaite K, George JT, Anderson RA (2014). "The kisspeptin-GnRH pathway in human reproductive health and disease". Human Reproduction Update. 20 (4): 485–500. doi:10.1093/humupd/dmu009. PMC 4063702. PMID 24615662.

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Kisspeptin

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