LASP1

LASP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I35
Identifiers
Aliases	LASP1, MLN50, LIM and SH3 protein 1, LASP-1
External IDs	OMIM: 602920; MGI: 109656; HomoloGene: 4480; GeneCards: LASP1; OMA:LASP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,921,770 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,729,590 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; jejunal mucosa; ; mucosa of ileum; ; lactiferous duct; ; duodenum; ; stromal cell of endometrium; ; superficial temporal artery; ; trabecular bone; ; mucosa of paranasal sinus; ; thymus;
	Top expressed in
	retinal pigment epithelium; ; conjunctival fornix; ; external carotid artery; ; ciliary body; ; internal carotid artery; ; epithelium of stomach; ; otic placode; ; saccule; ; Rostral migratory stream; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion transmembrane transporter activity; actin filament binding; actin binding; protein binding; metal ion binding; cadherin binding;
Cellular component	cell cortex; extracellular exosome; cytoskeleton; focal adhesion; cortical actin cytoskeleton; cytoplasm;
Biological process	ion transmembrane transport; ion transport; positive regulation of signal transduction; transport;
	Sources:Amigo / QuickGO
Orthologs
	3927
	16796
	ENSG00000002834
	ENSMUSG00000038366
	Q14847
	Q61792
	NM_001271608; NM_006148
	NM_010688
	NP_001258537; NP_006139
	NP_034818
	Wikidata
View/Edit Human	View/Edit Mouse

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.^[5]^[6]

This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000002834 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038366 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
^ ^a ^b "Entrez Gene: LASP1 LIM and SH3 protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000002834 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038366 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7490069-5] Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.

[entrez-6] "Entrez Gene: LASP1 LIM and SH3 protein 1".

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LASP1

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