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Large dense core vesicle (LDCVs) are lipid vesicles in neurons and secretory cells which may be filled with neurotransmitters, such as catecholamines or neuropeptides. LDVCs release their content through SNARE-mediated exocytosis similar to synaptic vesicles.[1] One key difference between synaptic vesicles and LDCVs is that protein synaptophysin which is present in the membrane of synaptic vesicles is absent in LDCVs.[2] LDCVs have an electron dense core which appear as a black circle in micrographs obtained with transmission electron microscopy.[1]
- ^ a b Edwards, Robert H (December 1998). "Neurotransmitter release: Variations on a theme". Current Biology. 8 (24): R883 – R885. Bibcode:1998CBio....8.R883E. doi:10.1016/s0960-9822(07)00551-9. ISSN 0960-9822. PMID 9843673.
- ^ Winkler, H. (1997-08-01). "Membrane Composition of Adrenergic Large and Small Dense Core Vesicles and of Synaptic Vesicles: Consequences for Their Biogenesis". Neurochemical Research. 22 (8): 921–932. doi:10.1023/A:1022410506476. ISSN 1573-6903. PMID 9239747.